Results 161 to 170 of about 9,409,646 (303)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Periódicos utilizados para publicação pelos pesquisadores de ciência da informação do Brasil e visibilidade nas bases de dados WoS e Scopus

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2014
Pinheiro, Liliana Vierira, Da Silva, Edna Lúcia, Rodríguez, Rosangela Schwarz   +2 more
doaj   +1 more source

Propellane-free access to bicyclo[1.1.1]pentanes. [PDF]

Nat Commun
Liu C, Li W, Li R, Merchant RR, Kanda Y, Qin T.   +5 more
europepmc   +1 more source

Unmet family planning needs among female refugees and asylum seekers in Germany - is free access to family planning services enough? Results of a cross-sectional study. [PDF]

Reprod Health, 2020
Inci MG, Kutschke N, Nasser S, Alavi S, Abels I, Kurmeyer C, Sehouli J.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

El govern obert als nous estats digitals : quines biblioteques per a quina ciutadania?

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2019
Peña-López, Ismael
doaj   +1 more source

The predictors of treatment adherence among hypertensive patients with cost-free access. [PDF]

Sci Rep
Nyande FK, Konlan KD, Asiamah LS, Boateng V, Gbeamir J, Dankwah V, Quaicoe R, Adedia D.   +7 more
europepmc   +1 more source

Access to justice: access to a free legal aid [PDF]

, 2002
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core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source