Results 111 to 120 of about 12,490 (212)

The Aesthetic Writings of Schiller. [PDF]

, 1929
Headstrom, Birger R.
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Quack-induced dermatitis: A case report of two dermatitis artefacta induced by quacks advise. [PDF]

Clin Case Rep
Pudasaini P, Adhikari S, Das K, Gorai S, Pamela RD.   +4 more
europepmc   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors. [PDF]

Cancer Metastasis Rev
Deschuyter M, Martin S, Salmanli C, Hubsch C, Vincent A, Meignan S, Furlan A, Cosset E, Burckel H, Noel G, Salzet M, Duhamel M, Raffo-Romero A, Boura C, Pinel S, Coca A, Joud A, Karnoub MA, Chastagner P, Raimbault S, Sudour-Bonnange H, Flacher V, Bernhard C, Entz-Werlé N.   +23 more
europepmc   +1 more source

Preclinical modeling of lower-grade gliomas. [PDF]

Front Oncol, 2023
Tang LW, Mallela AN, Deng H, Richardson TE, Hervey-Jumper SL, McBrayer SK, Abdullah KG.   +6 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells. [PDF]

Brain Pathol
Škarková A, Pelantová M, Tolde O, Legátová A, Mateu R, Bušek P, Garcia-Borja E, Šedo A, Etienne-Manneville S, Rösel D, Brábek J.   +10 more
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Derivation of Genetically Defined Murine Hepatoblastoma Cell Lines with Angiogenic Potential. [PDF]

Cancers (Basel)
Chen K, Toksoz A, Henchy C, Knapp J, Lu J, Ranganathan S, Wang H, Prochownik EV.   +7 more
europepmc   +1 more source