Results 131 to 140 of about 2,120,300 (293)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

py2DIC: A New Free and Open Source Software for Displacement and Strain Measurements in the Field of Experimental Mechanics. [PDF]

Sensors (Basel), 2019
Belloni V, Ravanelli R, Nascetti A, Di Rita M, Mattei D, Crespi M.   +5 more
europepmc   +1 more source

Bug-Fixing and Code-Writing: The Private Provision of Open Source Software [PDF]

Open source software (OSS) is a public good. A self-interested individual would consider providing such software, if the benefits he gained from having it justified the cost of programming.
Jürgen Bitzer, Philipp J. H. Schröder
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A catedral, o bazar e o condomínio: um ensaio sobre o modelo de negócio do software livre The cathedral, the bazaar and the condominium: an essay on a business model of free open source software

REGE Revista de Gestão, 2008
Este ensaio tem como objetivo apresentar o software livre como objeto viável de estratégia de comercialização no mercado de software. A partir da análise de seus efeitos sobre as receitas e o market share das firmas dominantes, o F/LOSS (Free/Libre Open ...
Guilherme Finkelfarb Lichand, Eduardo H. Diniz, Tania Pereira Christopoulos   +2 more
doaj  

VO₂FITTING: A Free and Open-Source Software for Modelling Oxygen Uptake Kinetics in Swimming and other Exercise Modalities. [PDF]

Sports (Basel), 2019
Zacca R, Azevedo R, Figueiredo P, Vilas-Boas JP, Castro FAS, Pyne DB, Fernandes RJ.   +6 more
europepmc   +1 more source

Leveraging Software, Advocating Ideology: Free Software and Open Source

, 2001
This paper uses the software program Linux and the discourse around it in order to examine how software programs can be used to articulate and defend social and economic positions. Although I do not use the term "expression" in a strict legal sense, I claim that in order to make policy decisions involving software, it is important to understand how the
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

FluxPyt: a Python-based free and open-source software for ¹³C-metabolic flux analyses. [PDF]

PeerJ, 2018
Desai TS, Srivastava S.
europepmc   +1 more source