Results 131 to 140 of about 1,973,708 (286)

Dynamics for a Ratio-Dependent Prey–Predator Model with Different Free Boundaries

Mathematics
In this paper, we study the dynamics of the ratio-dependent type prey–predator model with different free boundaries. The two free boundaries, determined by prey and predator, respectively, implying that they may intersect with each other as time evolves,
Lingyu Liu, Xiaobo Li, Pengcheng Li
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Existence of Local Solutions to a Free Boundary Problem for Compressible Viscous Magnetohydrodynamics

Mathematics
The motion of viscous compressible magnetohydrodynamics (MHD) is considered in a domain bounded by a free boundary. The motion interacts through the free surface with an electromagnetic field located in a domain that is exterior to the free surface and ...
Wiesław J. Grygierzec, Wojciech M. Zaja̧czkowski   +1 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Asymptotic behavior for a heat conduction problem with perfect-contact boundary condition

Electronic Journal of Differential Equations, 2003
In this paper we consider the heat conduction problem for a slab represented by the interval $[0,1]$. The initial temperature is a positive constant, the flux at the left end is also a positive constant, and at the right end there is a perfect contact ...
Andres Barrea, Cristina Turner
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A regularity result for incompressible elastodynamics equations in the ALE coordinates

Advanced Nonlinear Studies
We consider incompressible inviscid elastodynamics equations with a free surface and establish regularity of solutions for these equations. Compared with previous result on this free boundary problem [X. Gu and F.
Xie Binqiang
doaj   +1 more source

Self-similar solutions of a multi-phase Stefan problem on the half-line

Современная математика: Фундаментальные направления
In this paper, we study self-similar solutions of the multiphase Stefan problem for the heat equation on the half-line x 0 with constant initial data and Dirichlet or Neumann boundary conditions. In the case of the Dirichlet boundary condition, we prove
E. Yu. Panov
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source