Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Optimal Regularity and Structure of the Free Boundary for Minimizers in Cohesive Zone Models. [PDF]
Arch Ration Mech Anal, 2020 Caffarelli L, Cagnetti F, Figalli A.
europepmc +1 more source
Restructuring of emergent grain boundaries at free surfaces – an interplay between core stabilization and elastic stress generation [PDF]
, 2022 Xiaopu Zhang +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A high-order deferred correction method for the solution of free boundary problems using penalty iteration, with an application to American option pricing [PDF]
, 2022 Da‐Wei Wang +2 more
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Influence of Boundary Layer and Wake on Free Surface Flow around a Ship Model
, 1987 Mitsuhisa Ikehata, Yusuke Tahara
openalex +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Asymptotic behavior for a heat conduction problem with perfect-contact boundary condition
Electronic Journal of Differential Equations, 2003 In this paper we consider the heat conduction problem for a slab represented by the interval $[0,1]$. The initial temperature is a positive constant, the flux at the left end is also a positive constant, and at the right end there is a perfect contact ...
Andres Barrea, Cristina Turner
doaj
Compactness of the space of embedded minimal surfaces with free boundary in three-manifolds with nonnegative Ricci curvature and convex boundary [PDF]
, 2014 Ailana Fraser, Martin Man‐chun Li
openalex +1 more source