Results 161 to 170 of about 4,629,407 (316)

EasyCheck — Test Data for Free [PDF]

open access: yes, 2008
Jan Christiansen, Sebastian Fischer 0001
openaire   +1 more source

THE ROLE OF DEPUTY PRINCIPALS IN MANAGING CONFLICT AMONG SECONDARY SCHOOL TEACHERS IN THE LEJWELEPUTSWA DISTRICT, IN THE FREE STATE PROVINCE [PDF]

open access: yes, 2013
Thesis (Phd. (Psychology of education )) - Central University of Technology, Free State, 2013This purpose of this study was to investigate the role of the deputy principals in managing conflict among secondary school teachers in the Lejweleputswa ...
Mphatsoe, Mantwa. Florence.
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Can Free AI Tools Replace Statistical Software in Data Analysis?

open access: yesLabMed
Artificial intelligence (AI) has become increasingly integrated into scientific publishing, performing a vast array of tasks for enhancing research efficiency, analysis, and dissemination [...]
Giuseppe Lippi
doaj   +1 more source

A tool to assess the success of business intelligence implementation within Free State government departments : task technology fit perspective [PDF]

open access: yes, 2019
Thesis (Masters in Information Technology) -- Central University of Technology, Free State, 2019This study employed an information systems (IS) framework development based on a case study.
Moloabi, Tanki, Eusebia, Masekoala.   +1 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

VECTR: A Lightweight Requirements Prioritization Method for Software Startups Grounded in ROI, Time-to-Value, and Confidence

open access: yesComputers
Startups face critical challenges in prioritizing requirements under severe resource constraints. Although methods such as RICE and ICE are known, prior studies show that decisions often default to ad hoc judgments and stakeholder opinions.
Frédéric Pattyn   +4 more
doaj   +1 more source

A cost effective school management system for disadvantaged schools in the Free State province using the software as a service (SaaS) delivery model [PDF]

open access: yes, 2014
Thesis (M. Tech. (Information Technology)) -- Central University of technology, Free State, 2013The aim of this study was to create a dynamic software system that captures all information related to a student and delivers it to the educators, principal,
Kuriakose, Elizabeth B.
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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