Results 91 to 100 of about 5,295,129 (292)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Free Energy Principle for Biological Systems

Entropy, 2012
This paper describes a free energy principle that tries to explain the ability of biological systems to resist a natural tendency to disorder. It appeals to circular causality of the sort found in synergetic formulations of self-organization (e.g., the ...
Friston Karl
doaj   +1 more source

Kronecker's Double Series and Exact Asymptotic Expansion for Free Models of Statistical Mechanics on Torus

, 2002
For the free models of statistical mechanics on torus, exact asymptotic expansions of the free energy, the internal energy and the specific heat in the vicinity of the critical point are found.
Abramowitz M, Baxter R J, Cardy J L, Chin-Kun Hu, Christe P, E V Ivashkevich, Ferdinand A E, Gradshteyn I S, Hardy G H, Kasteleyn P W, Korn G A, McCoy B, Mumford D, N Sh Izmailian, Privman V, Prohorov Yu V, Salas J, Salas J, Sato M, Weil A   +19 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Friston, Free Energy, and Psychoanalytic Psychotherapy

Entropy
This paper outlines the ways in which Karl Friston’s work illuminates the everyday practice of psychotherapists. These include (a) how the strategic ambiguity of the therapist’s stance brings, via ‘transference’, clients’ priors to light; (b) how the ...
Jeremy Holmes
doaj   +1 more source

The Large N Limit of Toric Chern-Simons Matter Theories and Their Duals

, 2011
We compute the large N limit of the localized three dimensional free energy of various field theories with known proposed AdS duals. We show that vector-like theories agree with the expected supergravity results, and with the conjectured F-theorem.
A Amariti, A Amariti, A Amariti, A Amariti, A Amariti, A Butti, A Butti, A Giveon, A Gustavsson, A Hanany, A Hanany, A Hanany, A Kapustin, A Kapustin, Antonio Amariti, Claudius Klare, CP Herzog, D Berenstein, D Fabbri, D Forcella, D Martelli, D Martelli, D Martelli, D Martelli, DL Jafferis, DL Jafferis, DL Jafferis, DR Gulotta, DR Gulotta, DR Gulotta, E Witten, F Benini, F Benini, F Dolan, IR Klebanov, J Bagger, J Bagger, J Bagger, J Davey, KA Intriligator, M Aganagic, Massimo Siani, MS Bianchi, MS Bianchi, N Drukker, N Hama, O Aharony, O Aharony, O Aharony, S Benvenuti, S Benvenuti, S Cheon, S Franco, S Franco, S Franco, S Lee, S Minwalla, T Morita, V Niarchos, V Pestun   +59 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effective Free Energy for Individual Dynamics

, 2011
Physics and economics are two disciplines that share the common challenge of linking microscopic and macroscopic behaviors. However, while physics is based on collective dynamics, economics is based on individual choices.
Anderson S. P., Callen H., Dall'Asta L., Goodstein D., Mas-Colell A., Nadal J. P., Schelling T. C., Ui T.   +7 more
core   +2 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

The free energy cost of reducing noise while maintaining a high sensitivity

, 2015
Living systems need to be highly responsive, and also to keep fluctuations low. These goals are incompatible in equilibrium systems due to the Fluctuation Dissipation Theorem (FDT).
Sartori, Pablo, Tu, Yuhai
core   +1 more source