Results 101 to 110 of about 5,295,129 (292)
Localization of the Free Energy in Supergravity
Physical Review LettersWe derive a general formula for the gravitational free energy of Euclidean supersymmetric solutions to D=4, N=2 gauged supergravity coupled to vector multiplet matter. This allows one to compute the free energy without solving any supergravity equations, just assuming the solutions exist.
Pietro Benetti Genolini +4 more
openaire +5 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The free energy landscape of retroviral integration
Nature Communications, 2019 Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear.
Willem Vanderlinden +8 more
doaj +1 more source
Attention, uncertainty and free-energy
Frontiers in Human Neuroscience, 2010 We suggested recently that attention can be understood as inferring the level of uncertainty or precision during hierarchical perception. In this paper, we try to substantiate this claim using neuronal simulations of directed spatial attention and ...
Harriet eFeldman, Karl eFriston
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Free energy calculations in biomolecule-nanomaterial interactions
Frontiers in PhysicsIn computational chemistry and molecular modeling, the interactions between biomolecules (BMs) and nanomaterials (NMs) play a crucial role in various physical and biological processes, and have significant implications in material discovery and ...
Hongze Fu, Yinbang Zhu, Qu Chen
doaj +1 more source
Effective free energy for pinned membranes
, 2011 We consider membranes adhered through specific receptor-ligand bonds. Thermal undulations of the membrane induce effective interactions between adhesion sites. We derive an upper bound to the free energy that is independent of interaction details.
D. Chandler +6 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Minimal Self-Models and the Free Energy Principle
Frontiers in Human Neuroscience, 2013 The term "minimal phenomenal selfhood" describes the basic, pre-reflective experience of being a self (Blanke & Metzinger, 2009). Theoretical accounts of the minimal self have long recognized the importance and the ambivalence of the body ...
Jakub eLimanowski +3 more
doaj +1 more source