Results 121 to 130 of about 1,381,598 (313)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
An Approach to Alchemical Binding Free-Energy Calculations Using Coupled Topologies
, 2018 We present an approach to performing alchemical binding free energies which we term coupled topologies. Simultaneously coupling a molecule in the bound state while decoupling it in the unbound state allows us to calculate free energy changes where the ...
David, Huggins, David Huggins (5852048)
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Electronic Journal of Differential Equations, 2006 The Keller-Segel system describes the collective motion of cells which are attracted by a chemical substance and are able to emit it. In its simplest form it is a conservative drift-diffusion equation for the cell density coupled to an elliptic ...
Adrien Blanchet +2 more
doaj
The Free Energy Density of a Fluid and its Role in Solvation and Binding
The concept that a fluid has a position-dependent free energy density appears in the literature but has not been fully developed or accepted. We set this concept on an unambiguous theoretical footing via the following strategy.
Michael K., Gilson, Tom, Kurtzman
core +1 more source
, 2013 The pharmacological function of heroin requires an activation process that transforms heroin into 6-monoacetylmorphine (6-MAM), which is the most active form.
Zhan, Chang-Guo +4 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Two-State Folding over a Weak Free-Energy Barrier
, 2003 We present a Monte Carlo study of a model protein with 54 amino acids that folds directly to its native three-helix-bundle state without forming any well-defined intermediate state.
Free-energy Barrier +8 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Friston, Free Energy, and Psychoanalytic Psychotherapy
EntropyThis paper outlines the ways in which Karl Friston’s work illuminates the everyday practice of psychotherapists. These include (a) how the strategic ambiguity of the therapist’s stance brings, via ‘transference’, clients’ priors to light; (b) how the ...
Jeremy Holmes
doaj +1 more source