Results 101 to 110 of about 5,295,129 (293)

The computational anatomy of psychosis

Frontiers in Psychiatry, 2013
This paper considers psychotic symptoms in terms of false inferences or beliefs. It is based on the notion that the brain is an inference machine that actively constructs hypotheses to explain or predict its sensations.
Rick A Adams, Klaas Enno Stephan, Klaas Enno Stephan, Klaas Enno Stephan, Harriet R Brown, Christopher D Frith, Karl J Friston   +6 more
doaj   +1 more source

The Large N Limit of Toric Chern-Simons Matter Theories and Their Duals

, 2011
We compute the large N limit of the localized three dimensional free energy of various field theories with known proposed AdS duals. We show that vector-like theories agree with the expected supergravity results, and with the conjectured F-theorem.
A Amariti, A Amariti, A Amariti, A Amariti, A Amariti, A Butti, A Butti, A Giveon, A Gustavsson, A Hanany, A Hanany, A Hanany, A Kapustin, A Kapustin, Antonio Amariti, Claudius Klare, CP Herzog, D Berenstein, D Fabbri, D Forcella, D Martelli, D Martelli, D Martelli, D Martelli, DL Jafferis, DL Jafferis, DL Jafferis, DR Gulotta, DR Gulotta, DR Gulotta, E Witten, F Benini, F Benini, F Dolan, IR Klebanov, J Bagger, J Bagger, J Bagger, J Davey, KA Intriligator, M Aganagic, Massimo Siani, MS Bianchi, MS Bianchi, N Drukker, N Hama, O Aharony, O Aharony, O Aharony, S Benvenuti, S Benvenuti, S Cheon, S Franco, S Franco, S Franco, S Lee, S Minwalla, T Morita, V Niarchos, V Pestun   +59 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effective Free Energy for Individual Dynamics

, 2011
Physics and economics are two disciplines that share the common challenge of linking microscopic and macroscopic behaviors. However, while physics is based on collective dynamics, economics is based on individual choices.
Anderson S. P., Callen H., Dall'Asta L., Goodstein D., Mas-Colell A., Nadal J. P., Schelling T. C., Ui T.   +7 more
core   +2 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

The free energy cost of reducing noise while maintaining a high sensitivity

, 2015
Living systems need to be highly responsive, and also to keep fluctuations low. These goals are incompatible in equilibrium systems due to the Fluctuation Dissipation Theorem (FDT).
Sartori, Pablo, Tu, Yuhai
core   +1 more source

Localization of the Free Energy in Supergravity

Physical Review Letters
We derive a general formula for the gravitational free energy of Euclidean supersymmetric solutions to D=4, N=2 gauged supergravity coupled to vector multiplet matter. This allows one to compute the free energy without solving any supergravity equations, just assuming the solutions exist.
Pietro Benetti Genolini, Jerome P. Gauntlett, Yusheng Jiao, Alice Lüscher, James Sparks   +4 more
openaire   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effective free energy for pinned membranes

, 2011
We consider membranes adhered through specific receptor-ligand bonds. Thermal undulations of the membrane induce effective interactions between adhesion sites. We derive an upper bound to the free energy that is independent of interaction details.
D. Chandler, J. N. Israelachvili, M. Abramowitz, M. C. Beckerle, T. Weikl, Thomas Speck, W. Helfrich   +6 more
core   +1 more source