Results 101 to 110 of about 1,381,598 (313)
Rotation of Galaxies within Gravity of the Universe
Entropy, 2016 Rotation of galaxies is examined by the general principle of least action. This law of nature describes a system in its surroundings, here specifically a galaxy in the surrounding Universe.
Arto Annila
doaj +1 more source
Localization of the Free Energy in Supergravity
Physical Review LettersWe derive a general formula for the gravitational free energy of Euclidean supersymmetric solutions to D=4, N=2 gauged supergravity coupled to vector multiplet matter. This allows one to compute the free energy without solving any supergravity equations, just assuming the solutions exist.
Pietro Benetti Genolini +4 more
openaire +5 more sources
, 2021 Free-energy calculations play an important role in the application of computational chemistry to a range of fields, including protein biochemistry, rational drug design or material science.
Drazen, Petrov
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α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Brain activity and cognition: A connection from thermodynamics and information theory
Frontiers in Psychology, 2015 The connection between brain and mind is an important scientific and philosophical question that we are still far from completely understanding. A crucial point to our work is noticing that thermodynamics provides a convenient framework to model brain ...
Guillem eCollell, Jordi eFauquet
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Knowing one's place: a free-energy approach to pattern regulation.
, 2015 Understanding how organisms establish their form during embryogenesis and regeneration represents a major knowledge gap in biological pattern formation.
Levin, M +3 more
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The computational anatomy of psychosis
Frontiers in Psychiatry, 2013 This paper considers psychotic symptoms in terms of false inferences or beliefs. It is based on the notion that the brain is an inference machine that actively constructs hypotheses to explain or predict its sensations.
Rick A Adams +6 more
doaj +1 more source
, 2020 Rigorous binding free energy methods in drug discovery are growing in popularity due to a combination of methodological advances, improvements in computer hardware, and workflow automation.
Michael K., Gilson +5 more
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Predicting antibiotic resistance in complex protein targets using alchemical free energy methods
, 2021 Multi-drug resistant Mycobacterium tuberculosis requires a complex antibiotic treatment program and poses a major threat to tuberculosis (TB) treatment outcomes. Resistance is mostly conferred by chromosomal single nucleotide polymorphisms, many of which
Philip, Fowler, Alice, Brankin
core +1 more source