Results 41 to 50 of about 13,590 (284)

The Prominence Value of the Temporal Anchor of Free Indirect Discourse: A Comparison with the Perspectival Center

open access: yesDiscours, 2020
Free indirect discourse (FID) is a kind of speech or thought representation that lacks specific marking. The entity to whom the speech or thought is attributed (the perspectival center) has been shown to be a contextually available prominent protagonist (
Jakob Egetenmeyer
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Types of speech in the novel Mitrova Amerika by Petar Sarić [PDF]

open access: yesZbornik Radova Filozofskog Fakulteta u Prištini, 2019
The subject of this paper are different types of speech in the novel Mitrova Amerika written by Petar Sarić, a distinguished writer from Kosovo and Metohija.
Redžić Emilija D.
doaj  

Faire entendre la racialisation dans Écrits pour la parole de Léonora Miano

open access: yesItinéraires, 2022
In Écrits pour la parole, Léonora Miano gives a voice to the racialized people living in France. I will study how race gives shape to texts. I will see that Miano writes about the difficulty of speaking about race, by playing with the fragmenting of ...
Marion Coste
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Free Indirect Discourse. German and Russian Literature

open access: yesEnthymema
The paper first gives a definition of free indirect discourse (FID) and then characterizes the two main directions of its research. The more traditional one, is based on the application of the three modes of speech representation to the representation ...
Wolf Schmid
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Potential of Using Formalized Parameters for Modeling Speech Action

open access: yesНаучный диалог, 2021
The quantitative parameters characterizing direct and indirect connections of words in the composition of the associative field “polite” are studied on the basis of the “Project of a multilingual associative thesaurus of politeness”. The aim of the study
N. I. Stepykin
doaj   +1 more source

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