Results 101 to 110 of about 154,233 (325)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Hardware-in-the-loop Rendezvous Simulation using a Vision Based Sensor

, 2011
One of the critical issues of a satellite On-Orbit Servicing (OOS) mission is to ensure a safe and reliable Rendezvous and Docking (RvD) process. This most risky part of the mission must be carefully analyzed, simulated and verified before the mission ...
Boge , Toralf, Tzschichholz, Tristan, Benninghoff , Heike   +2 more
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The Borel cohomology of free iterated loop spaces

Algebraic & Geometric Topology
31 pages, major ...
Levy, Ishan, Wu, Justin
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Nicolai maps for supersymmetric sigma models

Journal of High Energy Physics
Supersymmetric field theories can be characterized by their Nicolai map, which is a nonlinear and nonlocal field transformation to their free-field limit.
Olaf Lechtenfeld
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

High-Frequency Electromagnetic Field Coupling to Small Antennae in a Rectangular Resonator

International Journal of Antennas and Propagation, 2012
The integral-differential equation for the current of an electrically small antenna, inside a resonator, which is induced by given sources, is approximately solved by the so-called “Method of Small Antenna,” both for dipole and loop antennas. The current
Sergey Tkachenko, Jürgen Nitsch, Moawia Al-Hamid   +2 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Sensitive optical free-space receiver architecture for coherent combining of deep-space communication signals through atmospheric turbulence [Elektronisk resurs]

High data rate optical deep space communication links for future space missions need large capture area receivers that can efficiently couple light into a single-mode fiber.
Larsson, Rasmus,, Karlsson, Magnus,, Andrekson, Peter,   +2 more
core   +1 more source