Results 121 to 130 of about 18,052 (297)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

FREE MOVEMENT OF GOODS - QUANTITATIVE RESTRICTIONS - IN THE EUROPEAN COMMUNITY AND THE ASEAN ECONOMIC COMMUNITY [PDF]

open access: yes, 2006
My thesis consists of three main parts. The first part, Chapter 2, describes the legal framework regulating free movement of goods, with the focus on quantitative restrictions in the EC.
Le Huynh, Tan Duy
core  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

The functioning of the free trade zone of the countries of the Eurasian economic union in modern conditions

open access: yesНаука. Культура. Общество, 2019
Much attention has recently been paid to the issues of studying the current state of formation and development of the free trade network of the Eurasian economic Union (hereinafter — the EAEU).
Marina L. Vartanova
doaj  

Environmental Protection and the Free Movement of Goods : Emphasis on Waste Management [PDF]

open access: yes, 2015
The free movement of goods is one of the economic freedoms of the internal market guaranteed in the EU. It has been one of the founding objectives of the Union, which has preserved its status as a fundamental principle.
Siltala, Susanna
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Free movement of goods in European union common market [PDF]

open access: yes, 2010
碩士歐盟共同市場,是促進歐盟整合的主要動力之一,而參與共同市場的會員國們打破彼此之間經濟往來的藩籬,主要為達成內部貨物、人員、服務與資金之自由流通。其中,貨物自由流通更被形容是四大自由中的基石,所以本文主要探討歐體共同市場如何成功地廢除所有可能造成會員國間貿易障礙的過程,並且藉由歐洲法院在相關案例上作出的判決來了解存在於其間的困難。相較於其他歐盟整合領域,貨物自由流通在國內的相關學術研究較不常見,期藉由本論文之說明,能夠讓對此範疇有研究需要者,多一份參考的途徑。 本篇論文主要是採文獻分析法以及歷史研究法,
劉蘋儀; Liu, Ping-i
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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