Results 141 to 150 of about 2,661 (278)
The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley +1 more source
Abstract The stability of the West Antarctic Ice Sheet (WAIS) remains a major uncertainty in sea‐level projections, and geologic records provide important constraints on its past behavior. We present 40Ar/39Ar ages of biotite and hornblende grains from iceberg‐rafted debris (IRD) in two Amundsen Sea sediment cores (PC493 and PS58/254), located south ...
Patric Simões Pereira +7 more
wiley +1 more source
Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi +3 more
wiley +1 more source
A computational study of free-piston diesel engine combustion
This paper investigates the in-cylinder gas motion, combustion process and nitrogen oxide formation in a free-piston diesel engine and compares the results to those of a conventional engine, using a computational fluid dynamics engine model.
Roskilly AP, Mikalsen R
core
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess +3 more
wiley +1 more source
Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release
A fundamental mechanism for the simultaneous control of multiple magnetic valves is reported in a miniature soft robotic patch for intravesical drug delivery, enabling fully wireless and programmable liquid release. Integrated with a bioadhesive interface and induction‐coupling‐based liquid volume sensing, the soft robotic patch is promising to enable ...
Boyang Xiao +5 more
wiley +1 more source
Thiolated Polymers in 3D Bioprinting: Control of Gelation
Thiolated polymers are established as programmable bioinks for 3D bioprinting, integrating versatile crosslinking chemistries with redox‐responsive control. This work demonstrates how molecular design and external triggers define gelation kinetics, printability windows, and structural fidelity, enabling stable, high‐resolution constructs and advancing ...
Soheil Haddadzadegan +2 more
wiley +1 more source
ABSTRACT The advancement of 3D carbon nanostructures for next‐generation desalination membranes is hindered by limited control of the pore size to ensure effective salt rejection. Chemical functionalization and mechanical modification are known approaches to address the problem, while the combined effect of the two approaches remains unexplored.
Aleksandr S. Voronin +2 more
wiley +1 more source
Comparative Study of Wear Behavior of Hypereutectic Al-Si Piston Alloys Using Experimental and Numerical Methods. [PDF]
Tashev A +5 more
europepmc +1 more source
Free piston Stirling engines: A review
Shahryar Zare +1 more
openaire +1 more source

