Results 141 to 150 of about 2,661 (278)

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source

Reduced West Antarctic Ice Sheet Size During Prominent Quaternary Interglacials Constrained by Iceberg‐Rafted Debris Provenance in the Amundsen Sea

open access: yesGeophysical Research Letters, Volume 53, Issue 12, 28 June 2026.
Abstract The stability of the West Antarctic Ice Sheet (WAIS) remains a major uncertainty in sea‐level projections, and geologic records provide important constraints on its past behavior. We present 40Ar/39Ar ages of biotite and hornblende grains from iceberg‐rafted debris (IRD) in two Amundsen Sea sediment cores (PC493 and PS58/254), located south ...
Patric Simões Pereira   +7 more
wiley   +1 more source

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

open access: yesAdvanced Functional Materials, Volume 36, Issue 47, 11 June 2026.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi   +3 more
wiley   +1 more source

A computational study of free-piston diesel engine combustion

open access: yes
This paper investigates the in-cylinder gas motion, combustion process and nitrogen oxide formation in a free-piston diesel engine and compares the results to those of a conventional engine, using a computational fluid dynamics engine model.
Roskilly AP, Mikalsen R
core  

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess   +3 more
wiley   +1 more source

Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
A fundamental mechanism for the simultaneous control of multiple magnetic valves is reported in a miniature soft robotic patch for intravesical drug delivery, enabling fully wireless and programmable liquid release. Integrated with a bioadhesive interface and induction‐coupling‐based liquid volume sensing, the soft robotic patch is promising to enable ...
Boyang Xiao   +5 more
wiley   +1 more source

Thiolated Polymers in 3D Bioprinting: Control of Gelation

open access: yesAdvanced Materials, Volume 38, Issue 35, 23 June 2026.
Thiolated polymers are established as programmable bioinks for 3D bioprinting, integrating versatile crosslinking chemistries with redox‐responsive control. This work demonstrates how molecular design and external triggers define gelation kinetics, printability windows, and structural fidelity, enabling stable, high‐resolution constructs and advancing ...
Soheil Haddadzadegan   +2 more
wiley   +1 more source

Coupled Chemical and Mechanical Control of the Pore Size in Carbon Honeycomb Membranes for Water Desalination

open access: yesAdvanced Materials Interfaces, Volume 13, Issue 11, 9 June 2026.
ABSTRACT The advancement of 3D carbon nanostructures for next‐generation desalination membranes is hindered by limited control of the pore size to ensure effective salt rejection. Chemical functionalization and mechanical modification are known approaches to address the problem, while the combined effect of the two approaches remains unexplored.
Aleksandr S. Voronin   +2 more
wiley   +1 more source

Free piston Stirling engines: A review

open access: yesInternational Journal of Energy Research, 2019
Shahryar Zare   +1 more
openaire   +1 more source

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