Results 91 to 100 of about 1,418,478 (304)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Is Perfect Price Discrimination Really Efficient? An Analysis of Free Entry [PDF]

We analyze models of product differentiation with perfect price discrimination and free entry. With a fixed number of firms, and in the absence of coordination failures, perfect price discrimination provides incentives for firms to choose product ...
V. Bhaskar, Ted To
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Sustainable development and product development - friend or foe?

, 2010
Published ArticleSustainable development is the key issue for enabling the survival of human culture. Product development is sometimes seen as conflicting with the aims of sustainable development.
Holzbaur, U.D.
core  

Krein-space operators determined by free product algebras induced by primes and graphs

Special Matrices, 2017
In this paper, we introduce certain Krein-space operators induced by free product algebras induced by both primes and directed graphs. We study operator-theoretic properties of such operators by computing free-probabilistic data containing number ...
Cho Ilwoo, Jorgensen Palle E. T.
doaj   +1 more source

Gluten-Free Product Contribution to Energy and Macronutrient Intakes in Spanish Children and Adolescents with Celiac Disease. [PDF]

Foods, 2022
González MP, Ballestero-Fernández C, Fajardo V, Achón M, García-González Á, Alonso-Aperte E, Úbeda N.   +6 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Characterization of free light chain impurity in a bispecific antibody

mAbs
Bispecific antibodies (bsAbs) target two distinct binding sites, which enable novel mechanisms of action for the treatment of disease. Due to this structural complexity, bsAbs exhibit greater heterogeneity as compared to monospecific antibodies and may ...
Monica Sadek, Neelima Mantha, Steffen Lippold, Delia Li, Kyle Spitler, Ran Li, Phillip Spinosa, Bob Liu, Steven Luu, Nicholas Woon, Yeying Zhang, Jia Guo, Renee Yang, Jonathan Zarzar, Yi Yang   +14 more
doaj   +1 more source

Adipose-derived stem cell secretome as a cell-free product for cutaneous wound healing. [PDF]

3 Biotech, 2021
Ajit A, Ambika Gopalankutty I.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source