Results 71 to 80 of about 1,418,478 (304)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The Free Product of $q$-Matroids

open access: yesThe Electronic Journal of Combinatorics
We introduce the notion of the free product of $q$-matroids, which is the $q$-analogue of the free product of matroids. We study the properties of this noncommutative binary operation, making an extensive use of the theory of cyclic flats. We show that the free product of two $q$-matroids $M_1$ and $M_2$ is maximal with respect to the weak order on $q$-
Gianira N. Alfarano   +2 more
openaire   +3 more sources

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Client-centred design evolution via functional prototyping [PDF]

open access: yes, 2009
Published ArticleThe product design process involves communication of potential design solutions to customers. Fully functional prototypes are most suitable for this because they are readily accepted and allow simultaneous evaluation of all design ...
Campbell, R. Ian   +9 more
core  

ANALYSIS OF THE INFLUENCE OF FOOD CROP PRODUCTION, DOMESTIC GROSS PRODUCTS, AND MANUFACTURER PRICES ON COST INSURANCE FREIGHT IMPORT AND FREE ON BOARD IN INDONESIA

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2020
This study aims to acknowledge and find empirical evidence of the effect of food crop production on gross domestic product and producer prices on cost insurance, freight, imports and free on board.
Hartati S.
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

On the Root-Class Residuallity of Generalized Free Products

open access: yesМоделирование и анализ информационных систем, 2013
Let K be a root class of groups. It is proved that a free product of any family of residually K groups with one amalgamated subgroup, which is a retract in all free factors, is residually K.
E. A. Tumanova
doaj   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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