Results 131 to 140 of about 1,418,478 (304)
Product Choice and Product Switching [PDF]
This paper develops a model of endogenous product selection by firms. The theory is motivated by new evidence we present on the importance of product switching by U.S. manufacturers.
Andrew B. Bernard +2 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Reducing product diversity in higher education. [PDF]
Public systems of higher education have recently attempted to cut costs by providing financial incentives to institutions who reduce the diversity of their programs.
Kelchtermans, Stijn, Verboven, Frank
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Topological Entropy of Some Automorphisms of Reduced Amalgamated Free Product C
. Certain classes of automorphisms of reduced amalgamated free products of C -- algebras are shown to have Voiculescu--Brown topological entropy zero.
The Erwin +4 more
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The impact of product placement on consumer involvement in the South African automotive industry
, 2016 Dissertation (M.Com.(Business Management))--University of the Free State, 2016This study contributes to the effectiveness of product placement as a marketing communications strategy responsible for consumer involvement with the product.
Ntsike, 'Mapaseka Susan
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2014 The present invention relates to a gluten-free composition for preparation of gluten-free food product. The composition comprises of brewer’s rice and hydroxylpropyl methylcellulose.
Sulaiman, Rabiha +3 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source