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Archives of Biochemistry and Biophysics, 2002
Free radicals and reactive oxygen species (ROS) have been associated with the etiology and/or progression of a number of diseases and in aging. Many of the proteins oxidatively modified by free radicals contain side-chain carbonyl derivatives, which can be used as markers for protein oxidation.
P. Boon Chock +2 more
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Free radicals and reactive oxygen species (ROS) have been associated with the etiology and/or progression of a number of diseases and in aging. Many of the proteins oxidatively modified by free radicals contain side-chain carbonyl derivatives, which can be used as markers for protein oxidation.
P. Boon Chock +2 more
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Free Radicals and Carcinogenesis
Free Radical Research Communications, 1990The role of free radicals and active states of oxygen in human cancer is as yet unresolved. Various lines of evidence provide strong but inferential evidence that free radical reactions can be of crucial importance in certain carcinogenic mechanisms. A central point in considering free radical reactions in carcinogenesis is that human cancer is really ...
Gisela Witz, Bernard D. Goldstein
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Endometriosis and Free Radicals
Gynecologic and Obstetric Investigation, 1999Recent studies have shown that synthase for nitric oxide or scavenger enzymes is distributed throughout the endometrium. We have reported that endothelial nitric oxide synthase, originally identified in vascular endothelial cells, is distributed in glandular epithelial cells in the endometrium, peaking in the midsecretory phase.
Shinichi Igarashi +3 more
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Trends in Neurosciences, 2004
Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes.
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Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes.
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Annals of the New York Academy of Sciences, 1994
Necrotic cell death is usually a consequence of extensive insult to the cell, leading to release of intracellular contents and an inflammatory response. Apoptosis, however, is a physiological response to damaging influences that requires sufficient maintenance of homeostasis to allow execution of the pathway.
Katherine A. Wood, Richard J. Youle
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Necrotic cell death is usually a consequence of extensive insult to the cell, leading to release of intracellular contents and an inflammatory response. Apoptosis, however, is a physiological response to damaging influences that requires sufficient maintenance of homeostasis to allow execution of the pathway.
Katherine A. Wood, Richard J. Youle
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Biochemical and Molecular Medicine, 1996
Free radicals that appear during physiological processes may lead to apoptosis in some pathological conditions when antioxidant capacity of the tissue is surpassed. Additionally, free radicals are involved in the control of apoptosis; antioxidant agents suppress apoptosis induced by a variety of stimuli.
Elena Moldoveanu +2 more
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Free radicals that appear during physiological processes may lead to apoptosis in some pathological conditions when antioxidant capacity of the tissue is surpassed. Additionally, free radicals are involved in the control of apoptosis; antioxidant agents suppress apoptosis induced by a variety of stimuli.
Elena Moldoveanu +2 more
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Nature Chemistry, 2013
Thomas Tidwell reflects on the overlooked — but prescient — proposal by the British chemists Arthur Downes and Thomas Blunt for photochemical free-radical formation, decades before Moses Gomberg launched the field of radical chemistry by preparing triphenylmethyl, the first stable organic radical.
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Thomas Tidwell reflects on the overlooked — but prescient — proposal by the British chemists Arthur Downes and Thomas Blunt for photochemical free-radical formation, decades before Moses Gomberg launched the field of radical chemistry by preparing triphenylmethyl, the first stable organic radical.
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Photoionization of Free Radicals
International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry, 1974Since this is the first lecture at this Institute on photoionization and free radicals, permit me to take a few minutes to outline my concept of these terms.
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The Lancet, 1983
Free radicals have become a buzz word in experimental pathology and they are beginning to impinge on clinical practice.
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Free radicals have become a buzz word in experimental pathology and they are beginning to impinge on clinical practice.
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1999
A free radical is a species containing one or more unpaired electrons. Free radicals are electron-deficient species, but they are usually uncharged, so their chemistry is very different from the chemistry of even-electron electron-deficient species such as carbocations and carbenes.
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A free radical is a species containing one or more unpaired electrons. Free radicals are electron-deficient species, but they are usually uncharged, so their chemistry is very different from the chemistry of even-electron electron-deficient species such as carbocations and carbenes.
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