Results 21 to 30 of about 40,275 (223)

Measurement of "Free" Thyroxine in Serum

Clinical Chemistry, 1971
Abstract A dialysis method for determining "free" thyroxine in diluted serum is presented. The effect of a number of variables (pH, incubation time and temperature, buffer composition and concentration, protein concentration, and specimen dilution) was studied, and pertinent data are presented. Within-run precision (95% confidence limits)
N D, Lee, V J, Pileggi
openaire   +2 more sources

Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness

Journal of Ultrasonography, 2018
Objective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal serum concentrations of free thyroxine, suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children.
Małgorzata Rumińska, Ewelina Witkowska-Sędek, Anna Majcher, Michał Brzewski, Monika Krawczyk, Beata Pyrżak   +5 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Unusual ratio between free thyroxine and free triiodothyronine in a long-lived mole-rat species with bimodal ageing.

PLoS ONE, 2014
Ansell's mole-rats (Fukomys anselli) are subterranean, long-lived rodents, which live in eusocial families, where the maximum lifespan of breeders is twice as long as that of non-breeders.
Yoshiyuki Henning, Christiane Vole, Sabine Begall, Martin Bens, Martina Broecker-Preuss, Arne Sahm, Karol Szafranski, Hynek Burda, Philip Dammann   +8 more
doaj   +1 more source

The application of new concepts of the assessment of the thyroid state to pregnant women

Frontiers in Endocrinology, 2022
Recently proposed concepts regarding the nature and assessment of the thyroid state have provided a model more consistent with empiric evidence. It now appears likely that there are no such entities as thyroid set points and individual euthyroidism ...
Stephen P. Fitzgerald, Stephen P. Fitzgerald, Nigel G. Bean, Samuel P. Fitzgerald, Samuel P. Fitzgerald, Henrik Falhammar, Henrik Falhammar   +6 more
doaj   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

THYROID FUNCTION IN DOGS WITH VISCERAL LEISHMANIASIS

Ciência Animal Brasileira, 2016
Several non-thyroid factors such as age, breed, concomitant diseases and use of certain drugs might influence the diagnosis of hypothyroidism in dogs. Changes in the concentrations of thyroid hormones due to non-thyroid illnesses are named euthyroid sick
Mauro Jose Lahm Cardoso, Maira Melussi, Rafael Fagnani, Luciane Holsback, Thais Helena Patelli, Eunice Oba   +5 more
doaj   +3 more sources

Enzyme immunoassay for free thyroxin.

Clinical Chemistry, 1982
Abstract We describe a mathematical model for a single-tube enzyme immunoassay for free thyroxin (FT4), involving use of a thyroxin/horseradish peroxidase (EC 1.11.1.7) conjugate that does not interact with thyroxin-binding globulin. In the presence of serum two populations of unassociated, or free, immunologically active constituents ...
H H, Weetall, W, Hertl, F B, Ward, L S, Hersh   +3 more
openaire   +2 more sources

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source