Results 1 to 10 of about 13,578 (179)

Inherited defects of thyroxine-binding proteins. [PDF]

Best Pract Res Clin Endocrinol Metab, 2015
Thyroid hormones (TH) are bound to three major serum transport proteins, thyroxine-binding globulin (TBG), transthyretin (TTR) and human serum albumin (HSA). TBG has the strongest affinity for TH, whereas HSA is the most abundant protein in plasma. Individuals harboring genetic variations in TH transport proteins present with altered thyroid function ...
Pappa T, Ferrara AM, Refetoff S.
europepmc   +5 more sources

Evaluating Thyroid Function in Paediatric Nephrotic Syndrome in a Tertiary Care Hospital of Northern India: A Case-control Study [PDF]

Indian Journal of Neonatal Medicine and Research, 2022
Introduction: Nephrotic Syndrome (NS) is a glomerular disease characterized by oedema, hypoalbuminemia and substantial proteinuria, which includes loss of thyroxine binding globulin and thyroid hormones, often resulting in subclinical or overt ...
Koushal Kumar Khajuria, Ashima Badyal
doaj   +1 more source

Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches

Toxics, 2022
Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a significant threat to global public health. The harmful effects of smoking/nicotine affect every system in the human body.
Mohd Rehan, Ummer R. Zargar, Ishfaq A. Sheikh, Saif A. Alharthy, Majed N. Almashjary, Adel M. Abuzenadah, Mohd A. Beg   +6 more
doaj   +1 more source

Exploiting Blood Transport Proteins as Carborane Supramolecular Vehicles for Boron Neutron Capture Therapy

Nanomaterials, 2023
Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio, Edoardo Jun Mattioli, Francesco Zerbetto, Matteo Calvaresi   +3 more
doaj   +1 more source

T3 levels and thyroid hormone signaling

Frontiers in Endocrinology, 2022
The clinical availability of tissue-specific biomarkers of thyroid hormone (TH) action constitutes a “holy grail” for the field. Scientists have investigated several TH-dependent markers, including the tissue content of triiodothyronine (T3)—the active ...
Federico Salas-Lucia, Antonio C. Bianco
doaj   +1 more source

A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins

Frontiers in Endocrinology, 2023
The thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are under homeostatic control by the hypothalamic-pituitary-thyroid axis and plasma TH binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and ...
Anish D. Bagga, Brian P. Johnson, Qiang Zhang   +2 more
doaj   +1 more source

Laboratory Assessment of Thyroid Function in Patients with Proteinuria [PDF]

Journal of Biomedical & Clinical Research, 2018
Significant losses of functional proteins such as hormones and hormone-binding proteins are seen in patients suffering from proteinuria. Studies have reported loss of thyroid hormones and thyroxine-binding globulin in the urine.
Irena Gencheva-Angelova, Adelaida Ruseva, Juli I.Pastuhov   +2 more
doaj   +3 more sources

Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

Critical Care, 2021
Background Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate with physical functional impairments
Ilse Vanhorebeek, Inge Derese, Jan Gunst, Pieter J. Wouters, Greet Hermans, Greet Van den Berghe   +5 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status

JBMR Plus, 2021
The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert biologic effects.
Daniel D Bikle
doaj   +1 more source