Results 11 to 20 of about 13,578 (179)
Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer. [PDF]
PLoS ONE, 2016 Amyloid formation of the human plasma protein transthyretin (TTR) is associated with several human disorders, including familial amyloidotic polyneuropathy (FAP) and senile systemic amyloidosis.
Irina Iakovleva +8 more
doaj +1 more source
Hypothyroidism in hibernating brown bears
Thyroid Research, 2023 Brown bears hibernate throughout half of the year as a survival strategy to reduce energy consumption during prolonged periods with scarcity of food and water.
Anne Mette Frøbert +5 more
doaj +1 more source
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism
Case Reports in Endocrinology, 2021 Nephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins.
Vânia Benido Silva +5 more
doaj +1 more source
Journal of Translational Medicine, 2021 Background Major depressive disorder (MDD), common mental disorder, lacks objective diagnostic and prognosis biomarkers. The objective of this study was to perform proteomic analysis to identify proteins with changed expression levels after ...
Hye In Woo +4 more
doaj +1 more source
Structural and dynamics evidence for scaffold asymmetric flexibility of the human transthyretin tetramer. [PDF]
PLoS ONE, 2017 The molecular symmetry of multimeric proteins is generally determined by using X-ray diffraction techniques, so that the basic question as to whether this symmetry is perfectly preserved for the same protein in solution remains open.
Giuseppe Zanotti +7 more
doaj +1 more source
Crystals, 2021 Transthyretin (TTR) is a plasma homotetrameric protein that transports thyroxine and retinol. TTR itself, under pathological conditions, dissociates into partially unfolded monomers that aggregate and form fibrils.
Lidia Ciccone +4 more
doaj +1 more source
The thyroid hormone receptors modulate the skin response to retinoids. [PDF]
PLoS ONE, 2011 Retinoids play an important role in skin homeostasis and when administered topically cause skin hyperplasia, abnormal epidermal differentiation and inflammation. Thyroidal status in humans also influences skin morphology and function and we have recently
Laura García-Serrano +5 more
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Scientific Reports, 2021 25-Hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2D) need to be bound to carrier proteins to be transported to their target cells. The majority of either 25OHD or 1,25(OH)2D is bound to vitamin D-binding protein (DBP), a smaller fraction ...
Oleg Tsuprykov +5 more
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Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. [PDF]
PLoS ONE, 2009 Transthyretin (TTR) is one of thirty non-homologous proteins whose misfolding, dissociation, aggregation, and deposition is linked to human amyloid diseases. Previous studies have identified that TTR amyloidogenesis can be inhibited through stabilization
Satheesh K Palaninathan +8 more
doaj +1 more source
Bifunctional crosslinking ligands for transthyretin [PDF]
Open Biology, 2015 Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease ...
P. Patrizia Mangione +16 more
doaj +1 more source