Transverse relaxation time (T2) mapping in the brain with off‐resonance correction using phase‐cycled steady‐state free precession imaging [PDF]
Sean Deoni
openalex +1 more source
Reading an Anti-Free Will Text Affects Beliefs Related to Free Will Over Time: A Registered Report
Oliver Genschow +2 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Label-free time- and space-resolved exometabolite sampling of growing plant roots through nanoporous interfaces. [PDF]
Patabadige DEW +6 more
europepmc +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer. [PDF]
Lehto US +5 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Risk factors for caries-free time: longitudinal study in early childhood. [PDF]
Cabral MBBS +4 more
europepmc +1 more source

