Results 21 to 30 of about 5,672,660 (293)

Tyrosine kinase inhibitors as potential sensitizers of adoptive T cell therapy for hepatocellular carcinoma

Frontiers in Immunology, 2023
Hepatocellular carcinoma (HCC) is a high-incidence malignant tumor worldwide and lacks effective treatment options. Targeted drugs are the preferred recommendations for the systemic treatment of hepatocellular carcinoma.
Linjun Liang, Linjun Liang, Xiaoyan Wang, Shuying Huang, Yanwei Chen, Peng Zhang, Liang Li, Yong Cui   +7 more
doaj   +1 more source

Dietary intake of total vegetable, fruit, cereal, soluble and insoluble fiber and risk of all-cause, cardiovascular, and cancer mortality: systematic review and dose–response meta-analysis of prospective cohort studies

Frontiers in Nutrition, 2023
ObjectivesTo conduct a systematic review and meta-analysis of prospective cohort studies to investigate the association between total, vegetable, fruit, cereal, soluble and insoluble fiber intake and risk of all causes, cardiovascular disease (CVD), and ...
Feifei Yao, Jianping Ma, Yong Cui, Cuihong Huang, Ruiqi Lu, Fulan Hu, Xiaoming Zhu, Pei Qin   +7 more
doaj   +1 more source

An Experimental Investigation on the Effects of Limestone Fines in Manufactured Sands on the Performance of Magnesia Ammonium Phosphate Mortar

Buildings, 2022
Magnesium ammonium phosphate cement (MAPC) prepared with ammonium dihydrogen phosphate (NH4H2PO4, ADP) and dead-burned Magnesium oxide (MgO) is a new type of rapid patch repair material for concrete structures.
Wenting Mao, Chunpeng Cao, Xincheng Li, Jueshi Qian, Yudong Dang   +4 more
doaj   +1 more source

The African Continental Free Trade Agreement: Welfare Gains Estimates from a General Equilibrium Model

IMF Working Papers, 2019
In March 2018, representatives of member countries of the African Union signed the African Continental Free Trade Area (AfCFTA) agreement. This agreement provides a framework for trade liberalization in goods and services and is expected to eventually ...
Lisandro Abrego, Maria Alejandra Amado, Tunc Gursoy, Garth Peron Nicholls, Hector Perez-Saiz   +4 more
semanticscholar   +1 more source

Genome-wide sRNA and mRNA transcriptomic profiling insights into carbapenem-resistant Acinetobacter baumannii

Frontiers in Cellular and Infection Microbiology
IntroductionAcinetobacter baumannii (AB) is rising as a human pathogen of critical priority worldwide as it is the leading cause of opportunistic infections in healthcare settings and carbapenem-resistant AB is listed as a “super bacterium” or “priority ...
Yong Wei, Xuli Xin, Jiachun Zhang, Qifeng Liao, Yan Rong, Ying Zhong, Meiying Zhao, Jianping Ma, Song He   +8 more
doaj   +1 more source

Development of a DNA-encoded library screening method “DEL Zipper” to empower the study of RNA-targeted chemical matter

SLAS Discovery
To date, RNA-targeted chemical matter is under explored due to a lack of robust screening assays. In this study, we present a novel RNA-targeted small molecule screening approach using a specialized DNA-encoded library (DEL). Our findings reveal that the
Zhongyao Ma, Bin Zou, Jiannan Zhao, Rui Zhang, Qiaoqiao Zhu, Xiaofeng Wang, Linan Xu, Xiang Gao, Xinyue Hu, Wei Feng, Wen Luo, Min Wang, Yunyun He, Zhifeng Yu, Weiren Cui, Qi Zhang, Letian Kuai, Wenji Su   +17 more
doaj   +1 more source

Identification and validation of biomarkers related to mitochondria-associated endoplasmic reticulum membranes in type 2 diabetes mellitus using peripheral blood transcriptomics

European Journal of Medical Research
Background The pathological hallmarks of Type 2 diabetes mellitus (T2DM) are impaired insulin sensitivity and insufficient insulin secretion. As the primary insulin source, pancreatic β-cell decline or dysfunction is key to T2DM progression.
Sufen Li, Yanqiong Yan, Qianjun Luo, Ruifei Tian, Jiahe Yan   +4 more
doaj   +1 more source

Agreement Establishing The African Continental Free Trade Area

International Legal Materials, 2019
On May 30, 2019, the Agreement Establishing the African Continental Free Trade Area (AfCFTA) entered into force for the twenty-four countries that had deposited their instruments of ratification. When the remaining thirty-one member states of the African
J. Gathii
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Causality of immune cells and endometriosis: a bidirectional mendelian randomization study

BMC Women's Health
Background Endometriosis, a prevalent chronic condition, afflicts approximately 10% of women in their reproductive years. Emerging evidence implicates immune cells in the pathogenesis of endometriosis, particularly in angiogenesis, tissue proliferation ...
Ying Peng, Youheng Li, Lingmei Wang, Shenglai Lin, Hong Xu   +4 more
doaj   +1 more source