Results 51 to 60 of about 12,878,813 (328)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Free Will: Real or Illusion - A Debate [PDF]
, 2020 Debate on free will with Christian List, Gregg Caruso, and Cory Clark.
Caruso, Gregg D. +2 more
core
The intersection of free submonoids of a free monoid is free
Semigroup Forum, 1972 Several necessary and sufficient conditions exist for a submonoid of a free monoid to be free. For a few, see [1] through [6]. This short note uses one of these conditions, due to Schutzenberger (see [2], p. 119, or [4], Theorem 1.4) to establish that the intersection of free submonoids of a free monoid M is again free.
openaire +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Forum: Qualitative Social Research, 2005 Neuroscientists have reopened the longstanding question of whether human beings have free will. In this article, I analyze their claims to have experimentally falsified the existence of free will. In order to provide an existence proof for something, its
Uwe Laucken
doaj
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
“Free Will and Affirmation: Assessing Honderich’s Third Way” [PDF]
, 2017 In the third and final part of his A Theory of Determinism (TD) Ted Honderich addresses the fundamental question concerning “the consequences of determinism.” The critical question he aims to answer is what follows if determinism is true?
B Waller +12 more
core +1 more source
Studia Philosophica Estonica, 2010 Determinism seems incompatible with free will. However, even indeterminism seems incompatible with free will, since it seems to make free actions random. Popper contends that free agents are not bound by physical laws, even indeterministic ones, and that
Danny Frederick
doaj