Results 71 to 80 of about 4,952,966 (312)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Ideas y Valores, 2009 He defendido anteriormente que no somos libres en el sentido requerido para la responsabilidad moral y, a la vez, que la concepción de la vida sin este tipo de libertad no sería devastadora para la moralidad o para nuestra noción de significado en la ...
Derk Pereboom
doaj +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Free Will and Modal Responsibility
Ergo, An Open Access Journal of PhilosophyIn the last half-century increased awareness of modal issues has been brought to bear on the free will debate. It has been argued that the context dependence of possibility claims can be exploited to mount a defence of compatibilism, the idea being that ...
William Bondi Knowles
doaj +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A DEFENSE OF BUDDHISM, MEDITATION, AND FREE WILL: A THEORY OF MENTAL FREEDOM
Zygon, 2020 This is my response to the criticisms of Gregg Caruso, David Cummiskey, and Karin Meyers, in their roles as members of the “Author Meets Critics” panel devoted to my book, Buddhism, Meditation, and Free Will: A Theory of Mental Freedom at the 2019 ...
doaj +2 more sources
Will the free market bring exploitation?
South African Family Practice, 1986 No abstract available.
Sam Fehrsen
doaj +1 more source
Free will, moral responsibility and ADHD
, 2003 One of the oldest problems in philosophy concerns the relationship between free will and moral responsibility. If we adopt the position that we lack free will, in the absolute sense—as have most philosophers who have addressed this issue—how can we ...
Tait, Gordon
core +1 more source
Big free groups are almost free [PDF]
International Journal of Algebra and Computation, 2015 It is shown that the big free group (the set of countably-long words over a countable alphabet) is almost free, in the sense that any function from the alphabet to a compact topological group factors through a homomorphism. This statement is in fact a simple corollary of the more general result proven below on the extendability of homomorphisms from ...
openaire +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source