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Znaczenie intencji dla moralnej oceny czynu - stanowisko Daniela Wegnera (THE MEANING OF INTENTION FOR MORAL EVALUATION OF AN ACTION - DANIEL WEGNER VIEW) [PDF]
Analiza i Egzystencja, 2008 In the article, the author attempts to compare and confront Daniel Wegner's idea of a conscious will with the selected ethic doctrines in the context of relationship between intention and the moral evaluation of an action.
Marcin Cichosz
doaj
A Discretionary Case for Preservationism about Free Will
Humana.Mente: Journal of Philosophical Studies, 2022 How does the term ‘free will’ refer? This question seems to lie at the center of debates about whether the attitudes and practices that depend on our successful attributions of basic-desert-entailing moral responsibility ought to be preserved or ...
Kelly McCormick
doaj
Reflections on Sam Harris' "Free Will"
Rivista Internazionale di Filosofia e Psicologia, 2017 In his book Free Will Sam Harris tries to persuade us to abandon the morally pernicious idea of free will. The following contribution articulates and defends a more sophisticated model of free will that is not only consistent with neuroscience and ...
Daniel C. Dennett
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Free Will: A consensus gentium Argument [PDF]
Organon FThis argument for free will is a probabilistic one based upon two conjectures: first, that of consensus; namely, that a large majority of people believe that they and others have free will and second, that a priori proofs against the existence of free ...
William Hunt
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Free Acres group photo at 25th anniversary, Summer 1935
, 1935 Group photograph of Free Acres inhabitants - taken during the summer of 1935 at the 25th anniversary celebration of the existence of Free Acres. Anniversary activities included sports, games, a play, and a slide show capturing the history of Free ...
Crawford, Will
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
From free will to ultimate freedom [PDF]
Belgrade Philosophical AnnualThis essay begins with a discussion of free will, and finally offers a more robust theory of ultimate freedom. My basic claim is that ultimate freedom is compatible with complete scientific explanation of human choice in terms of preference.
Lehrer Keith
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