Results 111 to 120 of about 115,173 (332)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Digitizing freelance media labor: A class of workers negotiates entrepreneurialism and activism

open access: yesNew Media & Society, 2019
Due to economic instability and technological change in digital media industries, media organizations and educators have encouraged freelance media workers to see themselves as individual businesses rather than a class of workers that should collectively
Errol Salamon
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

“Grisaille reconstitution” as a colourless visible retouching method: the case of Les Puys d’Amiens, a set of paintings dating from the 16th century

open access: yesGe-conservación, 2020
An innovative visible retouching method was successfully attempted on a set of seven paintings, the Puys d’Amiens, amongst which three of them presented large losses. The challenge was to find a retouching solution that would enable presenting all seven
Séverine Françoise   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In Defence of Mercenarism [PDF]

open access: yes, 2010
The recent wars in Iraq and Afghanistan have been characterized by the deployment of large private military forces, under contract with the US administration.
Fabre, Cecile
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Promotion of freelance services in the digital environment

open access: yesЦифровая социология
The article analyses the concept of freelance (temporary, project employment) within the framework of new approaches to employment and changes in the perception of remote and hybrid forms of employment by society and business after the COVID-19 pandemic.
L. G. Akhmaeva
doaj   +1 more source

Trust and Disintermediation: Evidence from an Online Freelance Marketplace

open access: yesManagement Sciences, 2018
As a platform improves trust between the two sides of its market to facilitate matching and transactions, it faces an increased risk of disintermediation: with sufficient trust, the two sides may circumvent the platform to avoid the platform’s fees.
Grace Gu, Feng Zhu
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy