Results 121 to 130 of about 115,173 (332)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Influence of Work Environment Factors on Burnout Syndrome Among Freelancers

open access: yesPsychiatry International
The problem associated with the manifestation of burnout syndrome is the subject of ongoing interest. In recent years, occupational burnout has been actively studied among professionals in the helping professions (teachers, physicians, social workers ...
Youri Ianakiev, Teodora Medneva
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Vers un journalisme réifié ?

open access: yesCommunication, 2015
This article analyzes how the exclusion of freelance journalists from the core group of legitimate French journalists during the inter-war period can be interpreted as being simultaneously an indicator and a result of the social logic of reification of ...
Faïza Naït-Bouda
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

REMOTE WORK: TECHNOLOGIES AND EXPERIENCE OF THE ORGANIZATION

open access: yesВестник университета, 2019
The types of remote employment (distance work and freelance) have been considered. Directions of use of modern information technologies at the organization of remote employment have been indicated and their developed characteristic has been given.
F. Konobevtsev   +3 more
doaj   +1 more source

Strategic Engagement with the Media Industry [PDF]

open access: yes
Establishing and maintaining close links with industry to equip BA Journalism students with the professional skills needed in a constantly evolving media marketplace.
Leighton, Neil   +1 more
core  

The Solent Capital Compass Model of Employability [PDF]

open access: yes, 2013
This four page presentation holds the current Solent Capital Compass Model used for embedding employability in our curriculum, along with simple definitions aimed at students.
Jones, Rosy, Sant, Richard
core  

Net structure of subject-to-subject relations in the management of the system of administrative services provision [PDF]

open access: yes, 2017
The purpose of the work is to form the net structure of management of the system of administrative services provision on the basis of implementation of subject-to-subject interactions between state sector and civil society. Methodology.
Britchenko, Igor, Danshina, Yulya
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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