Results 171 to 180 of about 22,508 (244)

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DATASAPROX: standardised dataset from protocolled sampling of saproxylic beetles in continental France and Corsica. [PDF]

Biodivers Data J
Bosc C, Touroult J, Horellou A, Mériguet B, Brin A, Valladares L, Brustel H, Barnouin T, Soldati F, Delzons O, Buralli F, Braud Y, Calmont B, Herbrecht F, Etienne S, Roques A, Gouix N, Moulin N, Dodelin B, Delporte G, Pages J, Chambord R, Chabrol L, Yvinec JH, Bouget C.   +24 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

His Start-up Wants to Mimic Human Breast Milk Using Plants. [PDF]

ACS Cent Sci
Tjandra K.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Factors Influencing Medication Literacy in Young and Middle-Aged Patients with NYHA Class I-III Heart Failure After Percutaneous Coronary Intervention: A Qualitative Study. [PDF]

Patient Prefer Adherence
Li JY, Ren ZQ, Wang XC, Jiang WJ, Ding L, Li C, Huang PY, Wang LC, Chen L.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fascial plane blocks as diagnostic keys to persistent pain after hip replacement: Sequential PENG and sacral ESP approach. [PDF]

Saudi J Anaesth
Gentili L, Scimia P, Silvi I, Angeletti C.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Correction: Bacchi et al. First Report on the Presence of Toxic Metals and Metalloids in East Asian Bullfrog (<i>Hoplobatrachus rugulosus</i>) Legs. <i>Foods</i> 2022, <i>11</i>, 3009. [PDF]

Foods
Bacchi E, Cammilleri G, Tortorici M, Galluzzo FG, Pantano L, Calabrese V, Brunone M, Vella A, Macaluso A, Dico GML, Ferrantelli V.   +10 more
europepmc   +1 more source