Results 111 to 120 of about 6,227 (291)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Cooperation in the Gig Economy: Insights from Upwork Freelancers [PDF]
Existing literature predominantly focuses on how freelancers individually complete tasks and projects. Our study examines freelancers\u27 willingness to work collaboratively.
Riedl, Christoph, Fulker, Zachary
core +1 more source
"SQUID GAME": HUMAN IN THE WORLD OF CONTEMPORARY CAPITALISM
Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетіїCinema as an art form developed rapidly in the last century and has not lose its position in the 21st century. What we see on the screen is the embodiment of thoughts, actions, stories of people and society.
Sergey Manukyan
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A Review on Freelancing Platforms and Client-Freelancer Systems
The rapid growth of the digital economy has significantly increased the demand for freelancing platforms that connect clients with skilled professionals. This review paper analyzes various existing freelancing systems and platforms, focusing on, their features, methodologies, and limitations.
Sabale, Dr. Amar V. +5 more
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Partecipazione e ConflittoThis article explores how workers' autonomy is supported by Smart, the largest network of freelance cooperatives in Europe. Based primarily on ethnographic data, we argue that this case shows that workers' autonomy is not necessarily linked to being self-
Mathilde Mondon-Navazo +2 more
doaj +1 more source
Bridging the gap: Connecting local government with creative freelancers [PDF]
This policy brief is for local councils wanting to work with creative ...
May, Will, Ashton, Daniel, Jahan, Aiysha
core +1 more source