Results 131 to 140 of about 36,439 (343)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Evidence-Based Design: Theoretical and Practical Reflections of an Emerging Approach in Office Architecture [PDF]

, 2009
Evidence-based design is a practice that has emerged only relatively recently, inspired by a growing popularity of evidence-based approaches in other professions such as medicine.
Budgen, Andrew, Lonsdale, Nathan, Penn, Alan, Sailer, Kerstin, Turner, Alasdair   +4 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Re-articulating Autonomy and Solidarity. The Case of Smart: The Largest European Network of Freelance Cooperatives

Partecipazione e Conflitto
This article explores how workers' autonomy is supported by Smart, the largest network of freelance cooperatives in Europe. Based primarily on ethnographic data, we argue that this case shows that workers' autonomy is not necessarily linked to being self-
Mathilde Mondon-Navazo, Annalisa Murgia, Sarah de Heusch   +2 more
doaj   +1 more source

“Knowing Me, Knowing You” the Importance of Networking for Freelancers’ Careers: Examining the Mediating Role of Need for Relatedness Fulfillment and Employability-Enhancing Competencies

Frontiers in Psychology, 2019
Research has shown the importance of engaging in networking behaviors for employees’ career success. Networking behaviors can be seen as a proactive way of creating access to career-related social resources and we argue that this type of proactive career
Sofie Jacobs, Sofie Jacobs, Ans De Vos, Ans De Vos, David Stuer, David Stuer, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden   +10 more
doaj   +1 more source

What Does the Gig Economy Mean for Workers? [PDF]

, 2016
[Excerpt] Technological advancement and the proliferation of the smartphone have reshaped the commercial landscape, providing consumers new ways to access the retail marketplace.
Bradley, David H, Donovan, Sarah A, Shimabukuru, Jon O   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A Report on the Design Sub-Sector in London [PDF]

, 2008
Housed in the School of Creative Enterprise at the London College of Communication (University of the Arts), the Creative Industries Observatory (CIO) is a leading contributor to academic research and analysis within the creative industries, and a source
Cardoso, Eva, Carnicero, Laura, Dempster, Anna, Joel, Sian, Liu, Kai, Mould, Oli, Pezzana, Silvio Pierluigi, Roodhouse, Simon   +7 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Evidence-based design: theoretical and practical reflections of an emerging approach in office architecture [PDF]

, 2008
Evidence-based design is a practice that has emerged only relatively recently, inspired by a growing popularity of evidence-based approaches in other professions such as medicine.
Budgen, A., Lonsdale, N., Penn, A., Sailer, K., Turner, A.   +4 more
core