Results 191 to 200 of about 14,676 (335)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Learning from Winners: A Strategic Perspective of Improving Freelancers’ Bidding Competitiveness in Crowdsourcing

The rapid growth of crowdsourcing grants freelancers unprecedented opportunities to materialize their expertise by bidding in specific tasks. Despite lowering freelancers’ participation costs, the bidding mechanism meanwhile induces intense competition ...
Yang, Chaofan, Sun, Yongqiang, Tan, Chee-Wee, Xiong, Bingqing, Lim, Eric   +4 more
core   +1 more source

Openness in communication between managers and freelancers in the publishing business

, 1989
The purpose of this study was to investigate perceptions of openness in communication between managers and freelancers in the publishing business. Two particular conditions governing relations between managers and freelancers made a study of aspects of ...
Davis, Janet Barrell
core   +1 more source

GATmath and GATLc: Comprehensive benchmarks for evaluating Arabic large language models. [PDF]

PLoS One
AlBallaa S, AlTwairesh N, AlSalman A, Alfarhood S.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Visual prognosis following open globe injury: clinical characteristics and risk factors from Vietnam National Eye Hospital. [PDF]

Int J Ophthalmol
Huong PTT, Khanh Van TT, Van Anh BT, Hai Van HT, Dong PN.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Employment status and associated factors in working-age maintenance hemodialysis patients: a multicenter cross-sectional study. [PDF]

Ren Fail
Zhang L, Xu M, Peng Y, Zhao J, Li Y, Wang F, Ma Y.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

AI assessment changes human behavior. [PDF]

Proc Natl Acad Sci U S A
Goergen J, de Bellis E, Klesse AK.
europepmc   +1 more source