Results 41 to 50 of about 234,413 (355)

Is the summer aerosol over the Arctic controlled by regional atmospheric circulation or ice conditions? Trends and future implications [PDF]

Atmospheric Chemistry and Physics
Based on aerosol particle number size distributions measured ≥ 85° N on I/B Oden covering the summers of 1991, 1996, 2001, 2008, and 2018, regional atmospheric circulation regimes (nodes) delineated with self-organizing maps (SOMs) were investigated as ...
C. Leck, J. Heintzenberg, T. Nygård, T. Naakka   +3 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Developing Stable Freeze-Dried Functional Ingredients Containing Wild-Type Presumptive Probiotic Strains for Food Systems

Applied Sciences, 2023
Designing stable dried functional food ingredients and foods containing live probiotic cultures maintaining high viable cell loads at the time of consumption is a challenge for the industry.
Ioanna Prapa, Anastasios Nikolaou, Panayiotis Panas, Chrysoula Tassou, Yiannis Kourkoutas   +4 more
doaj   +1 more source

A Study of the Freezing Cycle in an Alaskan Stream : A Completion Report [PDF]

, 1973
The work upon which this report is based was supported in part by funds (Proj. A-012-ALAS) provided by the United States Department of the Interior, Office of Water Resources Research, as authorized under the Water Resources Act of 1964, as ...
Benson, Carl S.
core  

River ice responses to a warming Arctic—recent evidence from Russian rivers [PDF]

, 2014
This paper looks at the response of river ice to recent warming in the Arctic at six major downstream gauges on large Russian rivers flowing to the Arctic Ocean.
Lammers, Richard B., Shiklomanov, Alexander I.   +1 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Stability of blood‐based biomarkers of Alzheimer's disease over multiple freeze‐thaw cycles

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Freeze‐thaw instability may contribute to preanalytical variation in blood‐based biomarker studies. We investigated the effects of up to four freeze‐thaw cycles on single molecule array immunoassays of serum neurofilament light chain and ...
Ashvini Keshavan, Amanda Heslegrave, Henrik Zetterberg, Jonathan M. Schott   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source