Results 171 to 180 of about 11,085 (261)

Falls in Huntington's Disease: A Cross‐Sectional Analysis of Clinical Features and Potential Contributors

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Falls occur across all stages of Huntington's disease (HD) and are associated with poor quality of life and injury. However, there is limited information on falls in HD. Objective The aim was to investigate the clinical features potentially associated with falls in HD. Methods We conducted a cross‐sectional, analytical observational
Arthur Pena Ferreira, Sarah Edith Souza de Assis Leão, Ricardo Oliveira Horta Maciel, Débora Palma Maia, Aline Alvim Scianni, Francisco Eduardo Costa Cardoso   +5 more
wiley   +1 more source

Lessons Learned From a Delayed-Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease. [PDF]

Ann Clin Transl Neurol
Virmani T, Pillai L, Landes RD, Glover A, Doerhoff S, Kleiner J, Lotia M, Dhall R, Garcia-Rill E.   +8 more
europepmc   +1 more source

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

An initial machine learning model applied to local field potential data from the subthalamic nucleus to detect freezing of gait in Parkinson's disease. [PDF]

Front Neurol
Alberts JL, Cantlay P, Rosenfeldt AB, Felix C, Waltz C, Bazyk AS, Berki V, Malan N, Nagel S, Walter B, Liao J, Escobar D, Baker KB, Miller Koop M.   +13 more
europepmc   +1 more source

Unilateral Freezing of Gait in Normal Pressure Hydrocephalus after Stroke

Movement Disorders Clinical Practice, EarlyView.
Jose Portales, Matthew Feldman, Jason Margolesky   +2 more
wiley   +1 more source

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

German translation of the Characterizing Freezing of gait questionnaire: implementation of the TRAPD process. [PDF]

J Patient Rep Outcomes
Wilhelm A, Janssen J, Teufelhart M, Ehgoetz Martens K, Nieuwboer A, Augat P.   +5 more
europepmc   +1 more source

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, EarlyView.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source

RNA networks of lysosomal-related biomarkers in Parkinson's disease and their correlations with freezing of gait-associated genes. [PDF]

Front Genet
Qibin Z, Lin L, Yibiao C, Peng L, Huiqing W, Daoqing S, Lianghong Y.   +6 more
europepmc   +1 more source