Results 211 to 220 of about 167,453,479 (294)

GCH1 p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations

open access: yesMovement Disorders, EarlyView.
Abstract Introduction GCH1 has been implicated in Parkinson's disease (PD), but its risks variants and associations are not well defined. Objectives Our goal was to investigate the clinical relevance and PD risk associated with the GCH1 p.Ser80Asn variant.
Yi Wen Tay   +37 more
wiley   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering   +6 more
wiley   +1 more source

Directional Adaptive Deep Brain Stimulation: An Initial Report of Safety, Tolerability, and Effectiveness

open access: yesMovement Disorders, EarlyView.
Abstract Background Adaptive deep brain stimulation (aDBS) is a safe and effective therapy for people with Parkinson's disease (PWP). Utilization of directional aDBS has not been specifically evaluated. Objectives The goal is to report the first data on the safety, tolerability, and preliminary effectiveness of chronic, directional aDBS in PWP ...
Martijn Beudel   +18 more
wiley   +1 more source

Wear‐Activated Surface Engineering of Thermoplastic Polyurethane/Graphene Nanoplatelet Nanocomposites for Ice Friction Control

open access: yesPolymer Composites, EarlyView.
Wear‐activated surface engineering of TPU/GNP nanocomposites through improved filler dispersion and interfacial anchoring of functionalized graphene nanoplatelets, leading to finer post‐abrasion textures and enhanced ice traction. ABSTRACT Graphene‐reinforced thermoplastic polyurethane (TPU) composites offer a promising route for developing ...
Sara Zahmatkesh   +2 more
wiley   +1 more source

Repetitive transcranial magnetic stimulation for freezing of gait in Parkinson's disease: a systematic review and meta-analysis. [PDF]

open access: yesClin Park Relat Disord
Hamzeh LH   +10 more
europepmc   +1 more source

Evaluating the efficacy of obturator cryoneurolysis for hip adductor spasticity: An observational, prospective study

open access: yesPM&R, EarlyView.
Abstract Background Hip adductor spasticity is a common affliction among patients with disorders of the central nervous system. Cryoneurolysis is a novel intervention for spasticity involving the application of extreme cold to a nerve. This induces axonal breakdown, relieving spasticity.
Fraser MacRae   +2 more
wiley   +1 more source

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