Results 1 to 10 of about 582 (86)
Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model. [PDF]
Evid Based Complement Alternat Med, 2022 Parkinson’s disease (PD) is a complex, age‐related neurodegenerative disease that causes neuronal loss and dysfunction over time. An imbalance of redox potential of oxidative stress in the cell causes neurodegenerative diseases and dysfunction of neurons.
Saleem U +5 more
europepmc +2 more sources
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors. [PDF]
Br J Pharmacol, 2021 Background and Purpose Src homology 3‐domain growth factor receptor‐bound 2‐like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB1 receptors. SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and CB1 receptors co‐localize in axons and presynaptic boutons.
Dvorakova M +6 more
europepmc +2 more sources
Мiryachit: A Culture-Specific Startle Syndrome in the Saami People. [PDF]
Mov Disord Clin PractAbstract Background Miryachit is perhaps the most complex and least understood of the culture‐specific startle syndromes that include latah and the jumping Frenchmen of Maine. Objectives We carried out a field study to evaluate startle‐induced paroxysms in the Saami to determine if it is still endemic and, if so, to contrast it with the available ...
Selikhova M +3 more
europepmc +2 more sources
Are cannabidiol (CBD) levels in consumer food products well tested?—A review
Food Frontiers, Volume 4, Issue 4, Page 1778-1793, December 2023., 2023 This review explores the advantages and drawbacks of using cannabis and phytocannabinoids and highlights the need for precise and repeatable analytical methods to quantify controlled phytocannabinoids in consumer CBD products and foods. The controlled phytocannabinoids found in consumer CBD products are mostly safe, but specific restrictions on the ...
Shahida Anusha Siddiqui +7 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 29, Issue 8, Page 2111-2128, August 2023., 2023 In Parkinson's disease (PD), astrocytes lose their vitamin‐A (VA) content leading to VA extraction from the liver and triggering liver fibrosis. VA intake will be directed toward VA‐deficient astrocytes and restore VA content in both the brain and liver.
Nesrine Saeid El‐Mezayen +6 more
wiley +1 more source
Glia, Volume 71, Issue 3, Page 571-587, March 2023., 2023 Main Points Myeloid cells adopt an anti‐inflammatory phenotype in the midbrain and a pro‐inflammatory profile in the striatum of α‐synuclein‐overexpressing mice. Astrocytes in the midbrain of α‐synuclein mice are involved in the pro‐inflammatory reaction.
Leyre Basurco +17 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 10, Issue 3, June 2022., 2022 Adult female C57BL/6 mice treated with 1 mg/kg i.p. CP55,940 (cannabinoid receptor agonist) displayed less anti‐nociception, and lower type 1 cannabinoid receptor (CB1R) in spine, in metestrus than estrus. No other measured responses to CP55,940 were different between metestrus and estrus.
Hye Ji J. Kim +5 more
wiley +1 more source
The FASEB Journal, Volume 36, Issue 2, February 2022., 2022 Abstract In the striatum, cholinergic interneurons (CINs) have the ability to release both acetylcholine and glutamate, due to the expression of the vesicular acetylcholine transporter (VAChT) and the vesicular glutamate transporter 3 (VGLUT3). However, the relationship these neurotransmitters have in the regulation of behavior is not fully understood.
Ornela Kljakic +10 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Background and Objective. Clerodendrum wallichii Merr leaves are traditionally used for the treatment of fever, skin infections, inflammation, diarrhea, and dysentery. However, its pharmacological investigation is scarce and no data found on its effect on the liver.
Yujian Tian +7 more
wiley +1 more source
The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats
Brain and Behavior, Volume 10, Issue 8, August 2020., 2020 Pentadecapeptide BPC 157 is a novel mediator of Roberts cytoprotection and has bidirectional effects on the gut‐brain axis. BPC 157 effectively ameliorated ischemia/reperfusion injuries and as such is a possible new therapeutic solution in ischemic/reperfusion injuries.
Jakša Vukojević +10 more
wiley +1 more source