Results 11 to 20 of about 582 (86)
Pharmacology Research &Perspectives, Volume 8, Issue 2, April 2020., 2020 Abstract Recently, we identified a novel fatty acid amide hydrolase (FAAH) inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide]. The aim of the present study is to characterize the pharmacological profile of PKM‐833 in vitro and in vivo. PKM‐833 showed potent inhibitory activities against human and rat
Toshiya Endo +2 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020 The complex yet not fully understood pathophysiology of Parkinson’s disease includes an important molecular component consisting of oxidative status changes, thus leading to oxidative stress occurrence. While no particular evidence has been reported that describes the relationship between oxidative stress and the molecular mechanisms behind Parkinson’s
Madalina-Andreea Robea +8 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin +11 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.The monocyclic sesquiterpene α‐humulene elicited a significant anxiolytic‐like behavior in adult zebrafish and no observable acute toxicity. Pharmacological dissection suggested that this effect is independent of the benzodiazepine (BZD) binding site on the gamma‐aminobutyric acid (GABA) type A receptor (GABAAR), but it depends on the serotonin type 3 ...
Alex de Souza Borges +9 more
wiley +1 more source
Early Intervention in Psychiatry, Volume 20, Issue 7, July 2026.ABSTRACT Background Eating disorders (ED) and psychosis/psychotic‐spectrum disorders (PSD) have overlapping symptoms and may co‐occur in a variety of presentations. Due to its debilitating and life‐threatening risk, it is important for clinicians to be aware of how catatonia may present within these co‐occurrences.
Rosiel Elwyn
wiley +1 more source
Striatal Nitric Oxide Activity Better Predicts Motor Disability Than Proto‐Oncogenes
European Journal of Neuroscience, Volume 63, Issue 1, January 2026.The figure summarizes the experimental design in which mice received a single intraperitoneal injection of saline, haloperidol, metoclopramide, or L‐NOARG at different doses. Extrapyramidal (EPS) side effects were assessed using the catalepsy test and the Rota‐rod test.
Sonia Guerrero Prieto +3 more
wiley +1 more source
International Journal of Biomaterials, Volume 2025, Issue 1, 2025.Nanotechnology has emerged as a transformative field in recent years, greatly impacting medicine and healthcare with innovative solutions for complex diseases. Among these advancements, protein‐based metal nanoparticles have shown exceptional promise in treating chronic illnesses, owing to their high biocompatibility, biodegradability, customizable ...
Syed Muhammad Hasan +5 more
wiley +1 more source
Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.Ethnopharmacological Significance Schizophrenia, a complex psychiatric disorder with multifactorial etiology, profoundly affects patients’ behavior, cognition, affect, and thought processes. Given the stagnation in novel drug development, notable treatment‐related adverse effects, and suboptimal recovery rates, the identification of innovative ...
Sihan Zhao +5 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.The study demonstrates that rIGFBP2 treatment exacerbates Parkinson's disease through increasing oxidative stress, mitochondrial dysfunction, and apoptosis via the IGF‐1/IGF‐1R signaling pathway. ABSTRACT Aims Insulin‐like growth factor binding protein 2 (IGFBP2) is implicated in various neurodegenerative diseases.
Jing An +4 more
wiley +1 more source
Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding. [PDF]
Biomedicines, 2023 Ryazanova MA +6 more
europepmc +1 more source