Results 31 to 40 of about 14,641 (264)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

EUROPEAN RAILWAY INFRASTRUCTURE: A REVIEW [PDF]

open access: yesActa Logistica, 2018
Presented paper deals with important freight railway infrastructure review in the Europe. The shrinking situation on the road makes companies do to think more and more about alternative ways of transporting goods from remote industrial zones quickly ...
Lucia Knapcikova, Rob Konings
doaj   +1 more source

The freight landscape: Convergence and divergence in urban freight distribution

open access: yesJournal of Transport and Land Use, 2017
The paper introduces the concept of the freight landscape: the spatial distribution of freight activity and intensity in a metropolitan area. Using population and employment density information, a freight landscape matrix is calculated for four major metropolitan areas: New York, Los Angeles, Paris and Seoul.
Rodrigue, Jean Paul   +2 more
openaire   +5 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Assessment of the performance of railway transportation in Nigeria from 1970 to 2010

open access: yesScientific African, 2022
Railway transportation is globally seen as an environmentally-friendly mode of mass transit system. Hence, many countries have continued to take steps to enhance the efficiency of their rail transportation industry.
Chukwurah Gladys Ogochukwu   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Green Public Procurement for Accelerating the Transition towards Sustainable Freight Transport

open access: yesWorld Electric Vehicle Journal, 2022
Requests for emission reduction in the freight transport sector will be more intense in the coming years. One possible strategy to reduce emissions from freight transport is through utilising zero emission vehicles, which requires substantial investments
Hampus Karlsson   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A Metro Freight Plan for Mixed Passenger and Freight Transportation

open access: yesJournal of Advanced Transportation, 2022
This study proposes a metro freight plan for mixed passenger and freight transportation. First, this study explores the problem of single-line metro train service under mixed passenger and freight transportation. Then, comprehensively considering the constraints of metro train freight capacity, loading and unloading time, and train schedules, a metro ...
Yutao Ye, Junhua Guo, Lixin Yan
openaire   +2 more sources

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