Results 61 to 70 of about 4,059,547 (363)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
LE FRANÇAIS DANS LES HOPITAUX ALGÉRIENS :OUTIL DE COMMUNICATION OU SOURCE DE CONTROVERSE ? [PDF]
Studii de gramatică contrastivăIn Algerian hospitals, French holds a significant place despite a national language policy that exclusively promotes Arabic. This paradox raises debates about the use of French as an indispensable communication tool in the healthcare sector and its ...
Nihad Guenoune
doaj +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
French House, French Hype, French Touch
apropos [Perspektiven auf die Romania]Im Verlauf der 1990er Jahre findet in Frankreich im Bereich der elektronischen Musik eine Entwicklung statt, mit der das Land zu einem bedeutenden Standort auf der popmusikalischen Weltkarte wird. Das Etikett „French“ wird schnell zu einer Art Qualitätssiegel in der internationalen Wahrnehmung, die dazu geprägten Begriffe wie „French House“ werden fast
openaire +4 more sources
Zeitschrift für Wortbildung, 2020 This article examines French Verb-Noun compounds with Means value (couvre-pied 'blanket', lit. cover-feet), derived from stative bases. It shows that they are generally ambiguous between Means and Instrument reading.
Marie Laurence Knittel +1 more
doaj +1 more source
LINGUISTICS – CULTUROLOGY – LINGUOCULTUROLOGY – LINGUISTIC AND CULTURAL STUDIES
Концепт: философия, религия, культура, 2019 Linguistic and cultural studies is a section of linguoculturology that considers the characteristics of the country of the language being studied in their linguistic expression, the vector of which is determined by the professional orientation of the ...
L. G. Vedenina
doaj +1 more source
Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination [PDF]
, 2023 Sophie Ndaw, Aurélie Remy
openalex +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Superare BICS e CALP nell’offerta formativa linguistica universitaria in Italia
Linguae &: Rivista di Lingue e Culture Moderne, 2019 Contemporary language teaching for educational paths in binational degrees in Engineering is subject to some challenges. In particular the organisation and the graduality of linguistic teaching, according to the traditional subdivision in language for ...
Giovanni Favata, Paolo Nitti
doaj +1 more source