Results 51 to 60 of about 1,542,712 (292)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
, 2006 In Paris there is no experience more enchanting than wandering along the Seine on an Autumn afternoon, stopping every now and then to rifle through the stands of a bookiniste, only to discover a treasure: a 17th century map, a book of poems by Jacques ...
Pike, Deborah J
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The transformation of the image of national identity into translation: the case of The Misanthrope by Molière [PDF]
مطالعات زبان و ترجمهNowadays, translation studies can be used as a tool for analyzing literary texts in the field of imagology. Among literary texts, plays play an important role in presenting the image of the national identity of each country.
Sedigheh Sherkat Moghadam
doaj +1 more source
World Guide to Technical Information and Documentation Services. United Nations Educational, Scientific and Cultural Organization. Paris: UNESCO, 1969. 287 pp. Hardbound, $6.00; paper, $4.00 (available in U.S.A. from Unipub. Inc., P.O. Box 433, New York City, N.Y. 10016). [PDF]
, 2017 Excerpt: This very useful reference volume is a companion to UNESCO\u27s World Guide to Science Information and Documentation Services (1965). It lists and describes the principal centers in each country which provide technical information, either to all
Wilkinson, Ronald S.
core +3 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Comparison of the semantic levels of ascension of Prophet Muhammad (PBUH) and the Journey of Alexander [PDF]
Matn/Pizhūhī-i Adabī, 2018 The ascension of the Prophet Muhammad (PBUH) has had a great influence on the ascensions in Sufism. Moreover, its confirmation and description in many mystical texts indicates the narrator’s faith, while the ascension was influenced by the involvement of
ali abbasi, Kobra Bahmani
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source