Results 71 to 80 of about 26,582,856 (246)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Vector fitting realisation of exact time domain modal nonreflecting boundary condition [PDF]
, 2010 To employ the modal nonreflecting boundary condition (MNRBC) in cylindrical coordinates in the finite element time domain (FETD) method, a time domain kernel expression must be found that it is the inverse Laplace transform (ILT) of a known frequency ...
Bavelis, Konstantinos, Mias, Christos
core +1 more source
Approach to Stochastic Modeling of Power Systems
Electrical, Control and Communication Engineering, 2010 This paper presents an approach to modeling power system that contains sources of stochastic disturbance. It is based on frequency analysis of linearized model of power system.
Alexander Rubtsov
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Performance Bound Analysis of Analog Circuits in Frequency- and Time-Domain Considering Process Variations [PDF]
, 2013 In this article, we propose a new performance bound analysis of analog circuits considering process variations. We model the variations of component values as intervals measured from tested chips and manufacture processes.
ADOLFO ADAIR PALMA RODRIGUEZ +1 more
core
Analysis of Hand Tremor in Parkinson’s Disease: Frequency Domain Approach
Frontiers in Biomedical Technologies, 2020 Purpose: Parkinson's Disease (PD) is a neuro-degenerative interminable issue causing dynamic loss of dopamine-creating synapses, which is one of the most far reaching ailments after Alzheimer's infection. In this paper, a system for the classification of
Elham Samadi +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Role of Probe Attenuation in the Time-Domain Reflectometry Characterization of Dielectrics [PDF]
, 2010 The influence of the measurement setup on the estimation of dielectric permittivity spectra from time-domain reflectometry (TDR) responses is investigated.
Ferraris, S. +6 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source