Results 201 to 210 of about 5,871,149 (318)

10<sup>-21</sup>-Level optical frequency dissemination over 2067 km of noise-loaded field-deployed fiber network. [PDF]

open access: yesLight Sci Appl
Chen FX   +11 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Reconfigurable assembly, disassembly, and self-propulsion of microparticles via optoelectronic tweezers. [PDF]

open access: yesMicrosyst Nanoeng
Wang A   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Publisher Correction: The bandgap-detuned excitation regime in photonic-crystal resonators

open access: yesNature Communications
Yan Jin   +6 more
doaj   +1 more source

New Possibilities of AC/DC Direct Frequency and Voltage Conversion

open access: yes
New possibilities of frequency and voltage regulation have been discussed on the basis of analysis of sinusoidal frequency conversion process. Within the low value interval of modulating frequency, the proposed attitude allows to choose the scheme of ...
Stabulnieks, Jānis   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Hearing loss and postural balance performance in adults and the elderly in ELSA-Brazil. [PDF]

open access: yesRev Saude Publica
Padilha FYOMM   +7 more
europepmc   +1 more source

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