Results 81 to 90 of about 722,706 (299)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Optimal Adjacent Output Phase Difference Assignments in Generalized One-Dimensional Five-Beam Switching Matrices

open access: yesIEEE Journal of Microwaves
This paper discusses the optimal assignment of phase differences between adjacent output ports in a recently proposed generalized one-dimensional orthogonal switching matrix with five beams by considering the RF performance of the compared matrices ...
Shengjia Wu   +3 more
doaj   +1 more source

A HYBRID ALGORITHM FOR SOLVING FREQUENCY ASSIGNMENT PROBLEM IN CELLULAR NETWORK [PDF]

open access: yesJournal of Engineering Science and Technology, 2017
Frequency allocation problem is considered an NP problem which requires a large search space to find the optimal solution. This paper presents a hybrid algorithm between the Hopfield neural network and the tabu search techniques algorithm to allocate ...
TAYSEER S. ATIA, AHMMED Y. YOUSIF
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Knot Probabilities in Random Diagrams

open access: yes, 2015
We consider a natural model of random knotting- choose a knot diagram at random from the finite set of diagrams with n crossings. We tabulate diagrams with 10 and fewer crossings and classify the diagrams by knot type, allowing us to compute exact ...
Cantarella, Jason   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A general framework for coloring problems: old results, new results, and open problems [PDF]

open access: yes, 2003
In this survey paper we present a general framework for coloring problems that was introduced in a joint paper which the author presented at WG2003. We show how a number of different types of coloring problems, most of which have been motivated from ...
Broersma, H.J.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Enhancing Physical Layer Security in AF Relay Assisted Multi-Carrier Wireless Transmission

open access: yes, 2018
In this paper, we study the physical layer security (PLS) problem in the dual hop orthogonal frequency division multiplexing (OFDM) based wireless communication system.
Ali, Zain   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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