Results 41 to 50 of about 716,764 (308)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A temperature compensation method of measuring frequency for cylindrical vibratory gyroscope in frequency split trimming

MATEC Web of Conferences, 2018
In the process of frequency split trimming, the fluctuation of environmental temperature causes a deviation in measuring the natural frequency, which is bigger than the request trimming accuracy.
Hu Youwang, Zeng Kai, Wang Haofang, Liang Chang, Zhou Yongping, Sun Xiaoyan   +5 more
doaj   +1 more source

Seismic attenuation compensation with spectral-shaping regularization

Earth and Planetary Physics, 2022
Because of the viscoelasticity of the subsurface medium, seismic waves will inherently attenuate during propagation, which lowers the resolution of the acquired seismic records.
QiZhen Du, WanYu Wang, WenHan Sun, Li-Yun Fu   +3 more
doaj   +1 more source

On Preparing Entangled Pairs of Polarization Qubits in the Frequency Non-Degenerate Regime

, 2010
The problems associated with practical implementation of the scheme proposed for preparation of arbitrary states of polarization ququarts based on biphotons are discussed. The influence of frequency dispersion effects are considered, and the necessity of
A. G. White, A. V. Burlakov, A. V. Burlakov, D. F. V. James, D. Kaszlikowski, D. V. Horoshko, E. V. Moreva, G. Brida, H. Bechmann-Pasquinucci, H. Bechmann-Pasquinucci, M. Bourennane, M. Genovese, M. Rubin, M. V. Chekhova, M. V. Fedorov, P. G. Kwiat, P. G. Kwiat, S. P. Kulik, S. S. Straupe, S.-Y. Baek, T. E. Kiess, W. K. Wootters, Y. H. Kim, Y. H. Kim, Y. H. Shih, Yu. I. Bogdanov, Yu. I. Bogdanov   +26 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Ground Reaction Force Frequency Content During Gait in the Elderly: Falling and Foot Dominance Effects

The Journal of Engineering
The elderly population is experiencing a significant increase, which has led to a substantial rise in the rate of falls among them. These falls have serious consequences for their health.
Somayeh Mehrlatifan, Ali Fatahi, Davood Khezri   +2 more
doaj   +1 more source

Research on ultraprecision turning and profile-error compensation technology for multi-axis linkage [PDF]

Nanotechnology and Precision Engineering
In an ultraprecision turning process for small-diameter optical aspheric workpieces, tool-profile errors induce mid-frequency errors in the workpiece profile, limiting further improvements in precision.
Xipeng Guo, Jiabin Yuan, Wei Shi, Shaohui Yin   +3 more
doaj   +1 more source

Spontaneous spectral phase conjugation for coincident frequency entanglement [PDF]

, 2005
Spontaneous parametric processes pumped transversely with short pulses are studied under a unified framework, which proves that such processes can efficiently generate entangled photon pairs with time anticorrelation and frequency correlation ...
Psaltis, Demetri, Tsang, Mankei
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source