Results 41 to 50 of about 715,538 (308)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
MATEC Web of Conferences, 2018 In the process of frequency split trimming, the fluctuation of environmental temperature causes a deviation in measuring the natural frequency, which is bigger than the request trimming accuracy.
Hu Youwang +5 more
doaj +1 more source
Seismic attenuation compensation with spectral-shaping regularization
Earth and Planetary Physics, 2022 Because of the viscoelasticity of the subsurface medium, seismic waves will inherently attenuate during propagation, which lowers the resolution of the acquired seismic records.
QiZhen Du +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The Journal of EngineeringThe elderly population is experiencing a significant increase, which has led to a substantial rise in the rate of falls among them. These falls have serious consequences for their health.
Somayeh Mehrlatifan +2 more
doaj +1 more source
Spontaneous spectral phase conjugation for coincident frequency entanglement [PDF]
, 2005 Spontaneous parametric processes pumped transversely with short pulses are studied under a unified framework, which proves that such processes can efficiently generate entangled photon pairs with time anticorrelation and frequency correlation ...
Psaltis, Demetri, Tsang, Mankei
core
Two-Way Optical Frequency Comparisons Over 100km Telecommunication Network Fibers [PDF]
, 2014 By using two-way frequency transfer, we demonstrate ultra-high resolution comparison of optical frequencies over a telecommunication fiber link of 100 km operating simultaneously digital data transfer.
Amy-Klein, Anne +5 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source