Results 61 to 70 of about 166,145,613 (262)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fast TDOA and FDOA Estimation for Coherent Pulse Signals

International Journal of Antennas and Propagation, 2022
Time difference of arrival (TDOA) and frequency difference of arrival (FDOA) have been widely used for localizing temporally continuous signals passively.
Yan Liu, Fucheng Guo
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Source localization from time-differences of arrival using high-frequency communication signals [PDF]

OCEANS'11 MTS/IEEE KONA, 2011
Localization of underwater acoustic (UWA) sources using observed signals is a popular research topic that has many potential applications, both military and civilian (e.g., navigation of underwater vehicles, mine hunting, marine mammal studies). This work adopts an inverse problem framework where the temporal and spatial structure of multipath observed
Ehsan Zamanizadeh, Joao Gomes, Jose M. Bioucas-Dias   +2 more
openaire   +1 more source

Moving source geolocation algorithm and performance analysis using dual-satellites sequence measurements and calibration sources

Tongxin xuebao, 2015
The method for locating a moving source on earth using a sequence of time difference of arrival(TDOA)and frequency difference of arrival(FDOA)measurements pairs obtained by dual-satellites was presented in the presence of calibration sources with ...
Ding WANG, Li ZHANG, Ying WU
doaj   +2 more sources

A PORTABLE HF RECEIVING COMPLEX FOR FREGUENCY-AND-ANGULAR SOUNDING OF THE IONOSPHERE

Radio Physics and Radio Astronomy, 2014
The paper presents the functional diagram and principle of operation of a portable HF receiving complex intended for measuring angles of arrival, Doppler frequency shifts and group time delays of probe signals used for remote radio sensing of the ...
V. G. Galushko, A. S. Kascheev, S. B. Kascheev, I. I. Pikulik, Y. M. Yampolski   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source