Results 101 to 110 of about 5,425,503 (237)

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, EarlyView.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source

Monopulse direction finding for linear frequency modulation based frequency diverse array

, 2017
Novel methods for monopulse direction finding for linear frequency modulation based frequency diverse array (LFM-FDA) are introduced and experimental results are presented.
Simsek Demir, Turhaner, Arsen, Hizal, Altunkan, Demir, Şimşek, Altunkan Hizal, Arsen Turhaner   +5 more
core   +2 more sources

New Insights into Poly(Dichlorophosphazene) Synthesis via Me3Si─N═PCl3 Polymerization: An Experimental and Theoretical Study

Chemistry – A European Journal, EarlyView.
Poly(dichlorophosphazene) synthesis via Me3Si─N═PCl3 polymerization was reinvestigated using quantum chemical calculations and experiments. A cationic initiator (Ph3PCl2) enables ambient‐temperature polymerization through chloride‐catalyzed cationic pathways involving dissociation, nucleophilic chloride attack, and chain‐propagating species formation ...
Cornelius Knuth, Paul Strasser, Carmen Hoth, Joerg Harloff, Thomas Eickner, Ian Teasdale, Axel Schulz   +6 more
wiley   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Advancing mine pillar design: Evaluating traditional methods and integrating AI for enhanced stability of pillars in the Great Dyke, Zimbabwe

Deep Underground Science and Engineering, EarlyView.
B1 is bord width 1, B2 is bord width 2, L is the pillar length, W is the pillar width, red color and letter A represent the pillars, and white color and number 1 represent excavated areas. Pstress is the average pillar stress; σv is the vertical component of the virgin stress, MPa; and e is the areal extraction ratio. e = B o B o + B P ${\rm{e}}=\frac{{
Tawanda Zvarivadza, Hendrik Grobler, Peter Apata Olubambi, Moshood Onifade, Manoj Khandelwal   +4 more
wiley   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Navigating the Prescription Drug Information System. [PDF]

Clin Pharmacol Ther
Information on new prescription drugs is increasingly complex and fragmented, posing challenges for healthcare professionals, patients, and payers. Clinicians require concise, actionable guidance to support prescribing decisions, while patients seek to balance benefits and harms when making decisions aligned with their treatment goals.
Wang IV, Davis C, Forrest R, Cherla A, Siebert M, Cowden J, Walker S, Krishnamurti T, Bourgeois FT, Woloshin S, Wagner AK, Naci H.   +11 more
europepmc   +2 more sources

Exploiting frequency diverse array processing to improve SAR image resolution

, 2008
Cross-range resolution in spotlight synthetic aperture radar (SAR) is primarily a function of the angular extent (Deltathetas) over which data is collected.
Michael A. Saville, Farooq, Jawad, Jawad Farooq, Michael A. Temple, Saville, Michael A., Temple, Michael A.   +5 more
core   +1 more source