Results 81 to 90 of about 5,674,494 (231)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Designing Optimal Frequency Offsets for Frequency Diverse Array MIMO Radar

, 2023
Frequency diverse array (FDA) radars provide a potential solution to target localisation along the slant range and azimuth angle due to the range-angle-dependent transmit beampattern caused by the used frequency increments.
Maria Juhlin, Cheng, Jie, Juhlin, Maria, Wen-Qin Wang, Jakobsson, Andreas, Wang, Wen Qin, Jie Cheng, Andreas Jakobsson, Jakobsson, Andreas,, Juhlin, Maria,, Wang, Wen Qin,, Cheng, Jie,, Lund University.   +12 more
core   +1 more source

Value of Information of Improved Traceability in Fresh Produce Markets

Agribusiness, EarlyView.
ABSTRACT Traceability plays an important role in promoting a safe food supply by fostering transparent information exchange along the food supply chain. New technological innovations have the potential to improve traceability outcomes, as greater transparency along the food supply chain can aid in pinpointing precise origins of the contamination ...
Kelsey Vourazeris, Mark R. Manfredo, Michael N. Kozicki   +2 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Joint Decoupling Optimization of Frequency Offsets and Array Elements for Frequency Diverse Arrays

International Journal of Antennas and Propagation
Frequency diverse array (FDA) has a distance-angle–dependent beam direction map, which has a greater application advantage than phased array. However, due to the distance-angle coupling and periodicity of its beam direction map, it makes the parameter ...
Yuming Lu, Qinlin Li, Kefei Liao, Ningbo Xie, Hanbo Chen   +4 more
doaj   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Robust FDA-STAP Under Transmit Array Gain and Phase Error for Range Ambiguity

Eng
Frequency diverse array (FDA)-aided spacetime adaptive processing (STAP) is a useful approach to suppressing range-ambiguous clutter in airborne radars.
Di Song, Chunyu Song, Fangyu Wang, Jinmin Shi   +3 more
doaj   +1 more source

Harmonic-based Direction Finding via Time Modulated Frequency Diverse Array

This work proposes a Time Modulated Frequency Diverse Array (TM-FDA) architecture, innovatively configured for direction-finding purposes. The system is built by combining the standard frequency diverse array philosophy with a specific time modulation ...
Tiberi, Tommaso, Costanzo, Alessandra, Bastia, Lorenzo, Masotti, Diego   +3 more
core   +1 more source