Results 171 to 180 of about 5,674,494 (231)

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang   +16 more
wiley   +1 more source

Patient Experiences of Chronic Low Back Pain: Development of a Conceptual Model Based on a Targeted Literature Review and Qualitative Patient Interviews

open access: yesMusculoskeletal Care, Volume 24, Issue 4, December 2026.
ABSTRACT Purpose Chronic low back pain (CLBP) is a persistent, debilitating condition. The United States (US) Food and Drug Administration Patient‐Focused Drug Development Guidance recommends using patient‐reported outcome (PRO) measures to assess pain and function in clinical trials and document content validity of the measures based on patient ...
Ekin Seçinti   +12 more
wiley   +1 more source

Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings

open access: yesCancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Ntombikhona Fortunate Maphumulo   +2 more
wiley   +1 more source

Influence of Drying Methods on Phytochemical Retention of Moringa oleifera Leaves and Green Synthesis of Zinc Oxide Nanoparticles Using the Optimal Moringa oleifera Leaf Extract

open access: yesFood Science &Nutrition, Volume 14, Issue 11, November 2026.
Fresh Moringa oleifera leaves were evaluated under different drying conditions to identify the treatment with superior retention of bioactive compounds. The selected freeze‐dried extract was used for green synthesis of ZnO nanoparticles, which exhibited characteristic physicochemical properties, concentration‐dependent antioxidant and antibacterial ...
Tamanna Rahman   +4 more
wiley   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

open access: yesMedicinal Research Reviews, Volume 46, Issue 6, Page 1798-1823, November 2026.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Development and evaluation of X‐ray lithophanes as test objects for interventional procedure simulation

open access: yesMedical Physics, Volume 53, Issue 11, November 2026.
Abstract Background In the growing field of interventional radiology, emerging technologies implement the use of artificial intelligence (AI) to help tackle growing demands for treatment. Due to the anatomical differences in animals, volunteers offer the most realistic training and testing scenario, however safety considerations restrict rapid ...
Carlo Saija   +12 more
wiley   +1 more source

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