Results 191 to 200 of about 38,141 (258)

Addressing the challenges of immunogenicity, heterogeneity and tumorigenicity in the clinical translation of human embryonic stem cells. [PDF]

Stem Cell Res Ther
Xia L, Qin J, Ye S.
europepmc   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, Volume 13, Issue 25, 4 May 2026.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Assessing safety trends of withdrawn medications: A data-driven pharmacovigilance approach using growth models. [PDF]

Explor Res Clin Soc Pharm
Ghubade S, Shukla S.
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Proof of Concept for Tumor Mutational Burden Prediction Through Biophysical Analysis Based on UHF-Dielectrophoresis. [PDF]

Biosensors (Basel)
Daverat H, Blasco N, Robert S, Rovini A, Dalmay C, Lalloué F, Pothier A, Durand K, Naves T.   +8 more
europepmc   +1 more source

Development and validation of MethylCog, a blood DNA methylation proxy for cognition

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea, Lily Wang, David Lukacsovich, Devi Dhanekula, Wei Zhang, Conor Galvin, Mahesh Joshi, Lilah Besser, Tatjana Rundek, James E. Galvin   +9 more
wiley   +1 more source

A conformal piezoelectric microsystem for demographic-adaptive and calibration-free cuffless blood pressure monitoring. [PDF]

Nat Commun
Liang C, Jiang Z, Qiu S, Zhao L, Mao X, Yang X, Zhang Y, Zhao N.   +7 more
europepmc   +1 more source

Health Prognostics in Multi‐Sensor Systems Based on Multivariate Functional Data Analysis

Applied Stochastic Models in Business and Industry, Volume 42, Issue 3, May/June 2026.
ABSTRACT Recent developments in big data analysis, machine learning, Industry 4.0, and IoT applications have enabled the monitoring and processing of multi‐sensor data collected from systems, allowing for the prediction of the “Remaining Useful Life” (RUL) of system components.
Cevahir Yildirim, Alba M. Franco‐Pereira, Rosa E. Lillo   +2 more
wiley   +1 more source

Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease. [PDF]

Alzheimers Res Ther
Bacci JR, Karagianni S, Alexopoulou ZS, Moukaled S, Tato-Fernández C, Arunachalam P, Aslanyan A, Aye S, Rocha ASL, Crugel M, Fawad A, Sogorb-Esteve A, Schöll M, König A, Paterson RW.   +14 more
europepmc   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source