Results 141 to 150 of about 1,219,269 (316)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
LINEAR FREQUENCY DOMAIN PREDICTIONS OF DYNAMIC DERIVATIVES FOR THE DLR F12 WIND TUNNEL MODEL
, 2012 Structural loads for full aircraft configurations can be represented by evaluating dynamic derivatives over a wide parameter space mainly including different mode shapes, an- gle of attack and Mach numbers.
Hübner, Andreas R. +2 more
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Simulation of dielectric frequency response of transformer insulation system
, 2013 Frequency domain spectroscopy has been widely used to monitor the condition of insulation system in power transformers. For a core type of transformer, a simplified XY model of a duct has been developed which allows one to examine the contribution from ...
Yu, Guo, Chen, George
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
INDEPENDENCE TEST OF GAMELAN INSTRUMENTS SIGNAL IN TIME DOMAIN AND FREQUENCY DOMAIN
Jurnal Ilmiah Kursor: Menuju Solusi Teknologi Informasi, 2013 INDEPENDENCE TEST OF GAMELAN INSTRUMENTS SIGNAL IN TIME DOMAIN AND FREQUENCY DOMAIN aAtik Wintarti, bYoyon K. Suprapto, cWirawan a,b,cElectrical Engineering Dept., Faculty of Industrial Technology, Institut Teknologi Sepuluh Nopember, Surabaya 60111 ...
Atik Wintarti +2 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FMEformer: a frequency-domain enhanced transformer for cross-domain landslide extraction
International Journal of Digital EarthLandslides are among the most frequent and destructive geological hazards in mountainous regions, posing serious threats to infrastructure and human safety.
Lei Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source